叶柳娟

【摘 要】目的：研究精神分裂症中奥氮平血药浓度与疗效、不良反应的关系。方法：选取2019年9月至2020年10月98例精神分裂症患者为研究观察对象，所有患者给予奥氮平治疗，分析奥氮平血药浓度与疗效、不良反应之间的关系。结果：高浓度组、正常浓度组、低浓度组患者性别、年龄、治疗有效率、BMI比对无统计学意义（P>0.05）。AST、ALT、TC、HDL-C、LDL-C水平3组间比较无统计学意义（P>0.05）；TG、催乳素、HbA1c水平比对结果是高浓度组>正常浓度组>低浓度组，差异有统计学意义（P<0.05）。结论：奥氮平治疗中不同血药浓度会对患者TG、催乳素、HbA1c水平产生影响，改变患者出现不良反应的概率，因此应用药物进行治疗期间，可以通过进行血药浓度监测，确保患者安全。

【关键词】奥氮平血药浓度；精神分裂症；不良反应；HbA1c水平

To analyze the relationship between olanzapine plasma concentration and curative effect and adverse reactions

Ye Liujuan

The third people’s hospital of Foshan， Foshan Guangdong 528041， China

【Abstract】Objective：To study the relationship between olanzapine plasma concentration and curative effect and adverse reactions in schizophrenia.Methods：A total of 98 schizophrenic patients from September 2019 to October 2020 were selected as observation subjects. All patients were treated with olanzapine，to analyze the relationship between curative effect and adverse reactions of olanzapine in blood concentration.Results：There were no statistically significant differences in gender， age， treatment response rate and BMI in high concentration group， normal concentration group and low concentration group（P>0.05）.There were no significant differences in AST， ALT， TC， HDL-C and LDL-C levels among the three groups（P>0.05）.The comparison results of TG， prolactin and HbA1clevels were the high concentration group > the normal concentration group > the low concentration group had statistical significance（P<0.05）.Conclusion：Different blood drug concentrations in olanzapine treatment can affect the levels of TG， prolactin and HbA1c in patients，and change the probability of adverse events in patients，soduring the treatment，By monitoring blood drug concentration，Ensure patient safety.

【Key？Words】Plasma olanzapine concentration；Schizophrenia；Adverse reactions；HbA1c level

精神分裂症是一种尚未完全阐明病因的常见精神疾病，对人类健康危害极大，此病对患者思维、情感、行为影响大，发病后需要立即采取科学治疗[1]。本文研究以98例患者为研究观察对象，分析奥氮平药品血药浓度与疗效、不良反应的关系，以通过对奥氮平血药浓度监测来实现对不良反应的监测，有效提升此药物临床应用效果与安全性，助力患者优质恢复，报道如下。

1.1 一般资料

2019年9月至2020年10月收治于我院的首發或复发精神分裂症患者98例为研究观察对象。年龄29岁～80岁，平均年龄（39.48±4.19）岁，病程6个月～5年，平均病程（2.62±0.42）年，研究经本院伦理委员会核准，所有患者对本次研究知情同意。

1.2 方法

从患者病历中收集一般资料（性别、年龄、身高、体重、病程）、生化指标和奥氮平血药浓度等资料。……