徐新建 赵继东 曹丽敏 郭斌 杨杨 何明

【摘 要】目的：研究外周血NLR、PLR與食管小细胞癌临床预后的关系，并对此关系进行相关的讨论。方法：从我院2019年2月至2020年8月期间接收的SCEC患者中按比例随机抽取60名符合条件的患者作为研究对象，在对这些患者进行后续治疗前采集患者外周血检测血小板、淋巴细胞以及中性粒细胞等各项身体信息的数据情况，并通过专业方式计算出NLR和PLR的数据值，依照数据的中间值将这些数据分别分成四组，即高NLR组、高PLR组、低NLR组、低PLR组。采用Kaplan-Meier法计算出其适应生存的各项信息，这其中的差异采用Log-rank进行常规的检验。分析其单一组成原因和多项组成原因对SCEC患者生存期限的影响因素。结果：SCEC患者中的高数据值组合与低数据值组合相比较可以发现高数据值组合普遍处于广泛期（P<0.05）。从单一组成原因方面分析显示，年龄大于55岁、处于广泛期、肿瘤位置处于食管上段、没有接受过化学药物疗法也没有接受过放射性疗法、NLR≥3.1、PLR≥135.8是SCEC预后产生不良反应的影响因素（P<0.05）。从多项组成原因方面分析显示，年龄、分期、是否进行放射疗法治疗、NLR这些都是影响SCEC患者的生存期限的原因。结论：NLR、PLR数据值较高的SCEC患者的生存期限很短，NLR数据值升高是SCEC患者生存期限的独立不良预后至关重要的原因。

【关键词】食管小细胞癌；外周血NLR和PLR；临床应用价值

To investigate the relationship between peripheral blood NLR， PLR and clinical prognosis of small cell esophageal carcinoma

Xu Xinjian1， Zhao Jidong1， Cao Limin2， Guo Bin1， Yang Yang3， He Ming1 1.The Chest Surgery Department of the Fourth Hospital of Hebei Medical University， Shijiazhuang Hebei 050000， China； 2.Inspection Department of Hebei Children’s Hospital， Shijiazhuang Hebei 050000， China； 3.The Chest Surgery Department of Shijiazhuang Third Hospital， Shijiazhuang Hebei 050000， China

【Abstract】Objective：To study the relationship between peripheral blood NLR， PLR and the clinical prognosis of small cell esophageal carcinoma.Methods： 60 eligible patients were randomly selected from SCEC patients received in our hospital from February 2019 to August 2020. Before follow-up treatment， the data of peripheral blood platelet， lymphocyte， neutrophil and other physical information were collected， and the data values of NLR and PLR were calculated in a professional way， According to the intermediate value of the data， these data are divided into four groups， namely high NLR group， high PLR group， low NLR group and low PLR group. Kaplan Meier method was used to calculate the information of adaptive survival， and log rank was used to test the difference. The influencing factors of single and multiple causes on the survival time of SCEC patients were analyzed. Results：comparing the high data value combination with the low data value combination in SCEC patients， it can be found that the high data value combination is generally in the extensive stage（P<0.05）. The analysis of single component causes showed that the influencing factors of adverse reactions in SCEC prognosis were age greater than 55 years old， extensive stage， tumor location in the upper esophagus， no chemotherapy or radiotherapy， NLR≥3.1 and PLR ≥ 135.8（P<0.05）.The analysis of multiple causes showed that age， stage， radiotherapy and NLR were the reasons affecting the survival time of SCEC patients.Conclusion：the survival time of SCEC patients with high NLR and PLR data is very short.The increase of NLR data is an important reason for the independent poor prognosis of SCEC patients.

【Key？Words】Small cell carcinoma of esophagus； NLR and PLR in peripheral blood； Clinical application value

对食管小细胞癌（SCEC）预后性影响因素的研究和分析有利于在学术上形成新的治疗方法，缓解SCEC患者病理上的发病症状，使医学专家根据新的信息不断地进行治疗方法的改进，最终研究出一种有效治疗SCEC疾病的治疗方法[1]。……