黄晓程 贤晓丽

【摘 要】目的：讨论胰岛素抵抗型多囊卵巢综合征（ Polycystic ovary syndrome，简称PCOS）以二甲双胍治疗的效果。方法：取2020年7月—2021年7月我院胰岛素抵抗型PCOS患者82例，随机划成：对照、观察两组（各41例）。对照组罗格列酮治疗，观察组增加二甲双胍，比较两组的炎症因子、内分泌指标、糖代谢指标。结果：观察组的TNF-α、IL-18、CRP均低于对照组（P<0.05）；LH、T低于對照组，FSH高于对照组（P<0.05）；空腹血糖、空腹胰岛素、胰岛素抵抗指数均低于对照组（P<0.05）。结论：二甲双胍应用后，胰岛素抵抗型PCOS患者的炎症因子将被有效降低，且还能有效改善内分泌与糖代谢情况，值得肯定。

【关键词】胰岛素抵抗型；多囊卵巢综合征；二甲双胍；炎症因子；内分泌指标；糖代谢

To observe the clinical efficacy of metformin in the treatment of insulin-resistant polycystic ovary syndrome and its effect on the levels of inflammatory factors，endocrine indexes and glucose metabolism indexes in serum of patients

Huang Xiaocheng，Xian Xiaoli

Weihai Municipal Hospital affiliated to Shandong University， Weihai Shandong 264200， China

【Abstract】Objective： To discuss the effect of metformin treatment of Polycystic ovary syndrome （PCOS） with insulin resistance. Methods：From July 2020 to July 2021， 82 patients with insulin-resistant PCOS in our hospital were randomly divided into control group and observation group （41 cases in each group）. The control group was treated with rosiglitazone， the observation group was treated with metformin， and the inflammatory factors， endocrine indexes and glucose metabolism indexes of the two groups were compared. Results： The levels of TNF-α， IL-18 and CRP in the observation group were lower than those in the control group（P<0.05）. LH and T were lower than those in the control group， while FSH was higher than that in control group（P<0.05）. Fasting blood glucose， fasting insulin and insulin resistance index were lower than those in the control group （P<0.05）. Conclusion：After the application of metformin，which can effectively reduce inflammatory factors and improve endocrine and glucose metabolism in patients with insulin resistance PCOS， which is worthy of affirmation.

【Key？Words】Insulin resistance； Polycystic ovary syndrome； Metformin； Inflammatory factors； Endocrine index； Sugar metabolism

多囊卵巢综合征（PCOS）在临床较为频发，患病后可见明显的闭经、经量少、无排卵、不孕、脱发、肥胖、多毛等症状[1]。在病程时间的延长和年龄的增长下，机体的胰岛素抵抗与高脂血症、高胰岛素血症等也将随之发生，对患者身体健康有着极大破坏[2]。目前，临床还尚未清楚其具体的病理机制，因而临床治疗的难度也较大。研究显示，PCOS一般发生在已育女性中，且约有一半以上的患者均伴有程度不一的胰岛素抵抗现象[3]。最近几年，有专家认为机体中的慢性炎症也可能影响胰岛素抵抗，同PCOS出现也有着一定联系。二甲双胍则属能实现胰岛素抵抗剂炎症因子的有效改善，故本文将把此药用于胰岛素抵抗型PCOS患者中，并寻求其价值所在。现阐述如下。

1.1 一般资料

取2020年7月至2021年7月我院胰岛素抵抗型PCOS患者82例，随机划成：对照、观察两组。……