陈翠萍　沈伟明

【摘 要】 目的：观察自拟方联合西医对肝硬化失代偿期患者的肝功能和凝血功能的影响。方法：选择60例肝硬化失代偿期患者，随机分为对照组和治疗组，各30例。对照组给予常规西药治疗，治疗组在对照组基础上加用自拟中药方治疗，对两组的临床疗效、肝功能、AFP、凝血功能进行统计和比较。结果：治疗组的临床疗效总有效率优于对照组，差异有统计学意义（P<0.05）;治疗后，治疗组的ALT、AST和TBIL水平降低幅度高于对照组，差异均具有统计学意义（P<0.05）;治疗后，治疗组的PT、APTT和AFP指标的改善程度优于对照组，差异有统计学意义（P<0.05）。结论：自拟方联合西药治疗失代偿性肝硬化有较好的疗效，值得临床推广使用。

【关键词】 自拟方;西医;肝硬化失代偿期;肝功能;凝血功能

【中图分类号】R657.3+1   【文献标志码】 A    【文章编号】1007-8517（2020）18-0108-04

Effect of Self-made Prescription Combined with Western Medicine on Liver

Function and Coagulation Function in Patients with Decompensated Cirrhosis

CHEN Cuiping1 SHEN Weiming2

1.Beijing Street Community Health Center Of Yuexiu District，Guangzhou 510030 ，China;

2.Liurong Street Community Health Center Of Yuexiu District，Guangzhou 510180，China

Abstract：Objective To explore the effect of self-made prescription combined with western medicine on liver function and coagulation function in patients with decompensated cirrhosis. Methods 60 cases with decompensated cirrhosis were selected. They were randomly divided into the treatment group and the control group， with 30 cases in each group. Patients in the control group were given conventional Western medicine for treatment， and patients in the treatment group were added with self-made prescription on the basis of the control group for treatment. The clinical efficacy， liver function， AFP， and coagulation function between the two groups of patients were counted and compared. Results The total effective rate of the clinical efficacy in the treatment group was better than that in the control group， and the difference was statistically significant （P<0.05）. After treatment， the reduction of ALT， AST and TBIL levels in the treatment group was higher than that in the control group. The difference was statistically significant （P<0.05）. After treatment， the improvement of PT， APTT and AFP in the treatment group was better than that in the control group， and the difference was statistically significant （P<0.05）. Conclusion The self-made prescription combined with western medicine has good efficacy in the treatment of decompensated cirrhosis， and its safety is good. It has clinical research values and is worthy of being promoted and used clinically.

Keywords：Self-made Prescription; Western Medicine; Decompensated Cirrhosis; Liver Function; Coagulation Function

肝硬化是一種常见的慢性疾病，引起此病的原因有很多，其中以病毒性肝炎和慢性酒精中毒最为常见。临床上可将肝硬化分为代偿期和失代偿期，代偿期可无明显症状，但随着病情的进展，肝功能逐渐恶化，便进入失代偿期，患者很容易合并上消化道出血、腹水、肝性脑病、感染等并发症，最后导致患者出现肝衰竭、肝肾综合征、肝癌等严重疾病，甚至引起死亡[1]。目前西医主要采用抗病毒、护肝、利尿、加强营养等对症支持治疗，但效果一般，而近年很多研究报道显示中医在抗肝纤维化方面具有突出效果[2]，且能提高患者的生活质量，所以越来越多的学者倾向于中西医结合治疗此病[3]。本研究选取30例肝硬化失代偿期患者，在西药常规治疗的基础上加用自拟方剂治疗，现将研究结果报告如下。

1 资料与方法

1.1 一般资料 选取2017年8月至2019年5月本院收治的60例肝硬化失代偿期患者作为研究对象，随机分为对照组和治疗组，每组各30例。……