苦荞山楂速溶粉降血糖活性的研究
2020-11-02张璐



摘要 [目的]研究苦荞山楂速溶粉对四氧嘧啶模型大鼠的降血糖作用。[方法]通过比较各组大鼠体重、进食量和饮水量变化及空腹血糖(FBG)、糖耐量、肝脏组织超氧化物歧化酶(SOD)、丙二醛(MDA)含量等指标的差异,研究苦荞山楂速溶粉对四氧嘧啶模型大鼠的降血糖作用。[结果]降糖试验中,苦荞山楂速溶粉高、中、低剂量组可以有效控制大鼠体重下降、多饮多食的状况,显著降低大鼠血糖值,提高大鼠糖耐量和肝脏组织SOD活性,降低MDA含量。[结论]苦荞山楂速溶粉可以显著降低四氧嘧啶糖尿病大鼠的血糖浓度。
关键词 苦荞山楂速溶粉;黄酮;四氧嘧啶糖尿病
中图分类号 R285 文献标识码 A 文章编号 0517-6611(2020)19-0177-03
doi:10.3969/j.issn.0517-6611.2020.19.046
Abstract [Objective] To study the hypoglycemic effect of tartary buckwheat hawthorn instant powder on alloxan model rats. [Method] The hypoglycemic effect of tartary buckwheat hawthorn instant powder on alloxan model rats was studied by comparing the changes in body weight, food intake and water intake, fasting blood glucose (FBG), glucose tolerance, and SOD and MDA content in liver tissues. [Result] The results show that: In the hypoglycemic test, the highdose, mediumdose and lowdose groups of tartary buckwheat hawthorn instant powder could effectively control the weight loss of rats, and the condition of drinking more and eating more could significantly reduce the blood sugar value of rats, improve the glucose tolerance of rats, increase the SOD activity and reduce the MDA content in the liver tissues of rats. [Conclusion] The instant powder of tartary buckwheat hawthorn could significantly reduce the blood sugar concentration of alloxan diabetic rats.
Key words Instant powder of tartary buckwheat hawthorn;Flavonoids;Alloxan diabetes
作者簡介 张璐(1978—),男,山西阳泉人,高级工程师,硕士,从事中药提取、药理药效、产品开发等研究。
收稿日期 2020-04-04
糖尿病是一种具有遗传倾向、由多种原因引起的内分泌代谢病,是以胰岛素绝对或相对不足导致血糖及尿糖增高为主要特征,并且导致糖、脂肪、蛋白质代谢紊乱的疾病[1]。据世界卫生组织(WHO)报告,糖尿病已成为世界上位于恶性肿瘤、心脑血管疾病之后严重威胁人类健康的慢性非传染性疾病[2],且糖尿病呈低龄化发展日趋严重。目前,治疗糖尿病常采用胰岛素、磺脲类、双胍类和α-糖苷酶抑制剂等降血糖药物[3-4],长期使用存在许多副作用,容易造成胰岛素依赖。因此,研究开发具有预防和辅助降血糖的天然植物食品具有重要意义。
苦荞、山楂均具有降血糖、降血脂等多种生物活性。……
