谢丽华　廖君

〔摘要〕 目的 探讨治疗脑缺血再灌注损伤（cerebral ischemia reperfusion injury， CIRI）的高频用药，并揭示用药与证型、组分与组分的关系，从组分层面解析中药治疗CIRI的配伍规律。方法 收集中国知网（1998-08-25至2018-08-25）20年期刊文献数据库中治疗CIRI的中药及相关组分的研究，采用关联规则Apriori计算方法，对治疗CIRI的中药复方及相关组分的研究结果进行挖掘分析。结果 高频次药物包括补阳还五汤、川芎嗪注射液、黄芪提取物等，印证及推测出构成丹参、三七等单味中药的活性成分及血栓通注射液和脑心通胶囊等中药复方的药效物质基础，并发现了芍药苷-阿魏酸、黄芪甲苷-藁本内酯-阿魏酸等新的组分配伍形式。结论 基于关联规则，为CIRI中药组分配伍治疗挖掘高频用药、用药与证型、组分与组分的关联关系，可为组分配伍研发提供依据与参考。

〔关键词〕 脑缺血再灌注损伤;组分配伍;关联规则

〔中图分类号〕R255.2;R743.31       〔文献标志码〕A       〔文章编号〕doi：10.3969/j.issn.1674-070X.2020.01.015

〔Abstract〕 Objective To explore the high frequency Chinese medicine for ischemia cerebral reperfusion injury （CIRI）， reveal the relationship between the medication  and syndromes， and different components， and analyze the component compatibility regularity of Chinese medicine in the treatment CIRI from component level. Methods The research on the Chinese medicine and related components for treating CIRI in the CNKI （1998-08-25 to 2018-08-25） 20-year periodical literature database were collected， and the association rule Apriori algorithm was used to perform mining analysis of the research results of Chinese medicine for CIRI and its related components. Results The high-frequency drugs included Buyang Huanwu Decoction， Ligustrazine Injection， Radix Astragali seu Hedysari Extract， etc.， which confirmed and speculated the active ingredients that made up the single Chinese medicine such as Radix Salviae Miltiorrhizae and Radix Notoginseng， and medicinal effect base of Chinese medicine compound such as Xueshuantong Injection and Naoxintong Capsule， and found new groups of compatibility such as paeoniflorin-ferulic acid， astragaloside-4， ligustilide-ferulic acid， etc. Conclusion Based on the association rules， this paper explores the high-frequency medications， medications and syndrome types， component and component associations for the Chinese medicine component compatibility in the treatment of CIRI， which can provide basis and references for the development of component compatibility research.

〔Keywords〕 cerebral ischemia reperfusion; component compatibility; association rule

腦卒中亦称脑中风，是一种突发性脑血液循环异常的疾病，包括脑出血和脑缺血，是临床常见的严重威胁人类健康的疾病之一，脑缺血性卒中尽早恢复缺血区脑组织的血液再灌注，使其重新获得血氧供应是临床上的首要治疗原则，而缺血后血流的再通可导致脑组织的缺血再灌注损伤（cerebral ischemia reperfusion injury， CIRI）[1]。近年来研究表明，许多中药对CIRI有一定的保护作用，中医药治疗在CIRI中得到了广泛的应用，并发挥着不可或缺的作用。而由于中药发挥临床疗效是通过多种活性成分协同作用的结果[2-3]，所以明确多药物联合运用的活性成分及配伍关系是中药应用的关键问题。……