陈志伟　谢淑华　凌华

【摘要】 目的：測定新生儿血清25羟维生素D水平，分析新生儿25羟维生素D水平差异的相关因素。方法：对2018年3月-2019年10月于本院新生儿科住院的151名新生儿在入院后24 h内进行血清25羟维生素D指标检测，分析不同胎龄、不同出生体重、不同性别住院新生儿血清25羟维生素D指标测定结果。结果：早期早产、中期早产、晚期早产、足月住院新生儿血清25羟维生素D指标测定结果相比，差异无统计学意义（P>0.05）;早期早产、中期早产住院新生儿血清25羟维生素D缺乏及血清25羟维生素D不足占比较足月住院新生儿增高，差异有统计学意义（P<0.05）;极低出生体重、低出生体重、正常体重住院新生儿血清25羟维生素D指标测定结果相比，差异有统计学意义（P<0.05）。男、女住院新生儿血清25羟维生素D指标测定结果相比，差异无统计学意义（P>0.05）。结论：新生儿血清25羟维生素D指标多存在缺乏或不足现象，不同胎龄、不同性别住院新生儿血清25羟维生素D指标之间差异性不明显，但不同出生体重住院新生儿血清25羟维生素D指标之间差异较大，需要加强重视以及关注。

【关键词】 新生儿 血清 25羟维生素D

doi：10.14033/j.cnki.cfmr.2020.21.014 文献标识码 B 文章编号 1674-6805（2020）21-00-03

Clinical Analysis of Serum Hydroxyvitamin D Levels in 151 Neonates/CHEN Zhiwei， XIE Shuhua， LING Hua. //Chinese and Foreign Medical Research， 2020， 18（21）： -36

[Abstract] Objective： To determine the serum 25-hydroxyvitamin D levels in neonates， and analyze the related factors of the differences in 25-hydroxyvitamin D levels in newborns. Method： A total of 151 newborns admitted to the neonatal department of our hospital from March 2018 to October 2019 were tested for serum 25-hydroxyvitamin D index within 24 hours after admission， and analyzed for different gestational ages， different birth weights， and different sexes result of determination of 25-hydroxyvitamin D in serum of newborns. Result： Early preterm birth， midterm preterm birth， late preterm birth， and term hospitalized newborns were compared with the measurement results of serum 25-hydroxyvitamin D index， there was no significant difference （P>0.05）. The serum 25-hydroxyvitamin D deficiency and the serum 25-hydroxyvitamin D not enough in Early preterm birth， midterm preterm birth newborns were relatively higher than term hospitalized newborns （P<0.05）. Compared with the measurement results of the 25-hydroxyvitamin D index in the serum of very low birth weight， low birth weight， and normal weight hospitalized newborns， the numerical item contents， the difference was statistically significant （P<0.05）. Compared with the results of determination of 25-hydroxyvitamin D in serum of male and female hospitalized newborns， there was no statistically significant difference in the content of the numerical items （P>0.05）. Conclusion： There is a lack or deficiency of 25-hydroxyvitamin D indicators in neonatal serum. There is no significant difference in serum 25-hydroxyvitamin D indicators in hospitalized newborns of different gestational ages and genders. The gap between D indicators is high， and more attention and attention are needed.

[Key words] Newborn Serum 25-hydroxyvitamin D

First-authors address： Shantou Second Peoples Hospital， Shantou 515041， China

维生素D为人体非常关键的一种维生素物质，维生素D和骨质疏松症、佝偻病等存在严密关系，维生素D和糖尿病、高血压、自身免疫性疾病等同样存在一定关系[1]。维生素D可对巨噬细胞、T淋巴细胞、树突状细胞、B淋巴细胞分化过程及生长过程予以调节，得到免疫调节作用，同时存在抵抗炎症效果[2]。新生儿为特殊人群，新生儿的体内营养素含量和其母亲体内环境存在密切关系，新生儿的维生素D由胎盘提供，新生儿母亲体内25羟维生素D情况和胎儿体内25羟维生素D状况存在密切相关性[3]。25……