胡妮

【摘要】 目的：本临床试验主要是為了对比不同宫颈锥切方法治疗宫颈上皮内瘤Ⅲ级的效果。方法：本次临床试验是将2017年6月30日-2019年6月30日在笔者所在医院妇科就诊的120例宫颈上皮内瘤Ⅲ级患者作为研究对象，采用随机数字分配法将120例患者分为试验组（n=60）和对照组（n=60），试验组应用宫颈冷刀锥切术治疗，对照组应用宫颈环形电切术进行治疗;分别观察两组手术期间各项指标、术后并发症发生率及HPV持续感染率等情况。结果：试验组术中出血量为（32.57±12.67）ml，手术时间为（18.25±9.25）min，均低于对照组的（44.12±11.68）ml、（25.26±10.27）min，试验组术后1、3、6个月的HPV持续感染情况（0、1、4例）少于对照组（3、7、11例）;且试验组HPV持续感染率为8.33%，显著低于对照组的35.00%，试验组并发症的发生率为13.33%，显著低于对照组的43.33%，差异有统计学意义（P<0.05）。结论：宫颈冷刀锥切除术能在一定程度上缩短手术时间，减少手术期间的出血量，特别是还能有效减少术后并发症的发生率，对患者术后的恢复有较好的疗效，可作为一种有效的手术方式供临床医生选择，值得广泛推广。

【关键词】 宫颈上皮内瘤Ⅲ级 宫颈冷刀锥切除术 宫颈环形电切术

doi：10.14033/j.cnki.cfmr.2020.20.060 文献标识码 B 文章编号 1674-6805（2020）20-0-03

Comparative of the Therapeutic Effects of Different Cervical Conization Methods on Grade Ⅲ Cervical Intraepithelial Neoplasia/HU Ni. //Chinese and Foreign Medical Research， 2020， 18（20）： -147

[Abstract] Objective： To compare the different methods of cervical conization in the treatment of cervical intraepithelial neoplasia Ⅲ. Method： In this clinical trial， 120 patients with cervical intraepithelial neoplasia grade Ⅲ who were treated in the Department of Gynecology of our hospital from June 30， 2017 to June 30， 2019 were selected as the research objects， and 120 patients were randomly divided into the experimental group （n=60） and the control group （n=60）. The experimental group was treated with cervical cold scalpel conization， and the control group was treated with cervical circular electrotomy. The indexes during the operation， the incidence of postoperative complications and the rate of persistent infection of HPV in the two groups were observed respectively. Result： The amount of intraoperative bleeding in the experimental group was （32.57±12.67） ml， and the operation time was （18.25±9.25） min， which were lower than （44.12±11.68） ml，

（25.26±10.27） min in the control group. The persistent infection of HPV in the experimental group was 0， 1 and 4 cases respectively at 1， 3 and 6 months after the operation which were lower than 3， 7 and 11 cases in the control group. The HPV persistent infection rate in the experimental group was 8.33%， significantly lower than 35.00% in the control group. The incidence rate of complications in the experimental group was 13.33%， which was significantly lower than 43.33% in the control group， the differences were statistically significant （P<0.05）. Conclusion： The cervical cold scalpel conization can shorten the operation time and reduce the amount of bleeding during the operation to a certain extent， especially can effectively reduce the incidence of postoperative complications， and has a good effect on the recovery of patients after the operation. It can be used as an effective operation for clinicians to choose， and it is worth popularizing in clinical.

[Key words] Cervical intraepithelial tumor grade Ⅲ Cervical cold scalpel conization Cervical circular electrotomy

First-authors address： Ezhou Maternal and Child Health Hospital， Ezhou 436000， China

随着当代女性的生活压力及工作压力的不断加大，女性的生活习惯也随之变化而变化，从而导致女性相关妇科疾病的发病率也日益剧增，其中宫颈上皮内瘤变Ⅲ级的发病率显现出直线上升的趋势，且发病年龄趋于年轻化[1]。在临床上宫颈上皮内瘤变无明显的临床症状，仅有小部分患者出现充血、息肉、糜烂症状，较为严重的患者会出现宫颈肥大的症状。宫颈上皮内瘤变在临床上属于癌前期病变，也是癌前病变的统称，严重降低女性的生活质量及威胁着女性的生命健康[2-4]。本次研究主要是收集了2017年6月30日-2019年6月30日在筆者所在医院妇科就诊的120例宫颈上皮内瘤Ⅲ级患者作为研究对象，为了对比不同宫颈锥切方法治疗宫颈上皮内瘤Ⅲ级的效果，现将具体研究结果进行汇报。……