温小春 陈远城

【摘要】 目的：探讨血清S-100β蛋白和神经元特异性烯醇化酶（NSE）在脑出血患者中的表达。方法：采用回顾性分析方法，选取2018年3月-2019年3月笔者所在医院收治的脑出血患者45例为研究组，根据预后情况分为研究组A（预后恶劣24例）及研究组B（预后良好21例）;选取同期健康体检者45例为对照组。对全部患者進行血清S-100β蛋白和NSE检测，计算血清S-100β蛋白、NSE浓度平均值及峰值。结果：研究组血清S-100β蛋白、NSE浓度平均值、峰值均高于对照组，差异均有统计学意义（P<0.05）;研究组A血清S-100β蛋白、NSE浓度平均值、峰值均高于研究组B，差异均有统计学意义（P<0.05）。结论：脑出血患者血清S-100β蛋白、NSE浓度均高于健康人群。此外，可将血清S-100β蛋白、NSE用于脑出血患者预后评估中。

【关键词】 血清S-100β蛋白 神经元特异性烯醇化酶 脑出血

doi：10.14033/j.cnki.cfmr.2020.20.022 文献标识码 B 文章编号 1674-6805（2020）20-00-02

Expression of Serum S-100β Protein and Neuron-specific Enolase in Patients with Cerebral Hemorrhage/WEN Xiaochun， CHEN Yuancheng. //Chinese and Foreign Medical Research， 2020， 18（20）： -58

[Abstract] Objective： To study the expression of serum S-100β protein and neuron-specific enolase in patients with cerebral hemorrhage. Method： A retrospective analysis was conducted in 45 patients with cerebral hemorrhage who admitted to our hospital from March 2018 to March 2019 as the study group. According to the prognosis， they were divided into the study group A （24 cases with poor prognosis） and the study group B （21 cases with good prognosis）. And 45 healthy subjects were selected as the control group. Serum S-100β protein and NSE were detected in all patients， and the mean values and peak values of serum S-100β protein， NSE concentration were calculated. Result： The mean values and peak values of serum S-100β protein and NSE concentration of the study group were higher than those of the control group （P<0.05）. The mean values and peak values of serum S-100β protein， NSE concentration in the study group A were higher than those of the study group B， and the differences were statistically significant （P<0.05）. Conclusion： The concentrations of serum S-100β protein and NSE in patients with cerebral hemorrhage were higher than those of the healthy population. In addition， serum S-100β protein and NSE can be used to evaluate the prognosis of patients with cerebral hemorrhage.

[Key words] Serum S-100β protein Neuron-specific enolase Cerebral hemorrhage

First-authors address： The Third Affiliated Hospital of Sun Yat-sen University， Yuedong Hospital， Meizhou 514011， China

脑出血是临床中常见的脑血管疾病，发病率与病死率均较高。引发脑出血的因素较多，早期干预能够显著提高患者预后质量。在临床进行治疗时，掌握患者相关指标水平对采取干预措施具有重要意义。本次研究主要分析血清S-100β蛋白、NSE在脑出血患者中的表达水平及对评估预后的价值。

1 资料与方法

1.1 一般资料

选取2018年3月-2019年3月笔者所在医院收治的脑出血患者45例，并选取同期健康体检者45例。纳入标准：经头颅CT检查确诊为脑出血。排除标准：合并其他严重器质性疾病;合并精神疾病。将45例患者作为研究组，并根据预后情况分为研究组A（入院2周后GOS 1～3分，预后恶劣）24例及研究组B（入院2周后GOS 4～5分，预后良好）21例。研究组A男13例，女11例;年龄（52.8±5.9）岁。研究组B男10例，女11例;年龄（53.4±5.5）岁。将健康体检者45例作为对照组，男28例，女17例;年龄（53.0±5.7）岁。三组一般资料比较，差异均无统计学意义（P>0.05）。

1.2 方法

采集研究组发病后72 h内静脉血，并采集对照组空腹静脉血。将……