慢性肾脏病3~5期患者肾脏相关指标与血清hs-cTnI的相关性分析
2020-06-08周金敬陈祺裕张文颖
周金敬 陈祺裕 张文颖

【摘要】 目的:探讨慢性肾脏病3~5期患者肾脏相关指标与血清超敏心肌肌钙蛋白I(hs-cTnI)的相关性。方法:选取2016年7月-2019年6月本院收治的慢性肾脏病3~5期患者100例,比较不同CKD分期患者血清hs-cTnI水平,分析血清hs-cTnI与慢性肾脏病患者肾脏相关指标之间的相关性。结果:不同CKD分期患者血清hs-cTnI水平比较,差异均有统计学意义(P<0.05)。血清hs-cTnI与CKD分期、血胱抑素C(cys C)及肾小球滤过率(GFR)有相关性(P<0.05),血清hs-cTnI与血白蛋白(ALB)、血尿素氮(BUN)及血肌酐(Scr)无明显相关性(P>0.05)。结论:血清hs-cTnI与CKD分期、cys C及GFR之间具有相关性。
【关键词】 慢性肾脏病 超敏心肌肌钙蛋白I CKD分期
Analysis of Correlation between Renal Related Indicators and Serum hs-cTnI in Patients with Chronic Kidney Disease Stage 3-5/ZHOU Jinjing, CHEN Qiyu, ZHANG Wenying. //Medical Innovation of China, 2020, 17(11): -163
[Abstract] Objective: To investigate the correlation between renal related indicators and serum hypersensitive cardiac troponin I (hs-cTnI) in patients with chronic kidney disease stage 3-5. Method: From July 2016 to June 2019, 100 patients with stage 3-5 chronic kidney disease admitted to our hospital were selected. Serum hs-cTnI levels in patients with different CKD stages were compared. The correlation between serum hs-cTnI and renal related indicators in patients with chronic kidney disease was analyzed. Result: The serum hs-cTnI level of patients with different CKD stages was compared, the differences were statistically significant (P<0.05). There were correlations among serum hs-cTnI and CKD stages, serum cystatin C (cys C) and glomerular filtration rate (GFR) (P<0.05), while there were no significant correlations among serum hs-cTnI and serum albumin (ALB), blood urea nitrogen (BUN) and serum creatinine (Scr) (P>0.05). Conclusion: There are correlations among serum hs-cTnI and CKD stage, cys C and GFR.
[Key words] Chronic kidney disease Hypersensitive cardiac troponin I CKD stage
First-authors address: Shenzhen Hospital, Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen 518057, China
doi:10.3969/j.issn.1674-4985.2020.11.040
有研究指出,导致发生心血管类疾病的一项独立风险因素就是慢性肾脏病,除此之外,导致慢性肾脏病患者死亡的主要原因之一就是心血管疾病,在死亡慢性肾脏病患者总数当中占比40%左右[1]。而在发生心血管疾病的患者当中,约25%会发展为急性心肌梗死,危及患者的生命安全[2]。所以,给予肾脏病晚期患者进行临床治疗的过程中,诊断患者是否发生心血管相关并发症是临床当中的一个关注点及重点[3]。超敏心肌肌钙蛋白I(hs-cTnI)是临床中诊断心血管类疾病一项重要的参考指标,特别是对急性心肌梗死(AMI)具有较高的预测敏感性及特异性[4]。本研究选取2016年7月-2019年6月
本院收治的慢性肾脏病3~5期患者100例,分析血清hs-cTnI水平與慢性肾脏病患者肾脏相关指标之间的相关性,旨在为晚期慢性肾脏病患者的诊疗提供更多的参考资料,现报道如下。
1 资料与方法
1.1 一般资料 选取2016年7月-2019年6月本院收治的慢性肾脏病3~5期患者100例。纳入标准:(1)符合临床中对慢性肾脏病的诊断标准[5];(2)CKD分期3~5期;(3)年龄40~80岁;(4)未接受临床治疗者。……
