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右美托咪定和丙泊酚在硬膜外麻醉手术中的应用对比

2019-04-21胡荣清

中外医学研究 2019年27期

胡荣清

【摘要】 目的:对比右美托咪定与丙泊酚在硬膜外麻醉手術中的应用价值。方法:选取笔者所在医院2018年1-12月接收的采取妇科手术治疗的70例患者为研究对象,随机分为两组,A组(n=35)采取右美托咪定麻醉,B组(n=35)采用丙泊酚麻醉,统计各组不同时间平均动脉压、心率、Ramsay镇静评分及不良反应发生率。结果:两组麻醉前及术后60 min平均动脉压、Ramsay镇静评分及心率对比差异无统计学意义(P>0.05);A组麻醉后15 min、术后15 min及手术完毕各项指标均优于B组,差异均有统计学意义(P<0.05)。A组不良反应发生率(5.71%)低于B组(25.71%),差异有统计学意义(P<0.05)。结论:右美托咪定在硬膜外麻醉手术中应用效果较丙泊酚更优,不仅具有良好的镇静、镇痛效果,同时有助于避免其他反应的发生。

【关键词】 硬膜外麻醉手术; 丙泊酚; 右美托咪定; Ramsay镇静评分

doi:10.14033/j.cnki.cfmr.2019.27.069 文献标识码 B 文章编号 1674-6805(2019)27-0-03

Comparison of the Application of Dextromethidine and Propofol in Epidural Anesthesia/HU Rongqing.//Chinese and Foreign Medical Research,2019,17(26):-162

【Abstract】 Objective:To compare the value of Dexmedetomidine and Propofol in epidural anesthesia.Method:Seventy patients who underwent gynecological surgery in our hospital from January 2018 to December 2018 were randomly divided into two groups.The group A(n=35) was anesthetized with Dexmedetomidine,and the group B(n=35) was anesthetized with Propofol.The mean arterial pressures,heart rates,Ramsay sedation scores and incidences of adverse reactions at different time were counted.Result:There was no significant difference in mean arterial pressure,Ramsay sedation score and heart rate in both groups before anesthesia and 60 min after operation(P>0.05).The indexes of 15 min after anesthesia,15 min in operation and at the end of the operation in group A were better than those in group B,the differences were statistically significant(P<0.05).The adverse reaction of group A(5.71%) was lower than 25.71% of group B(P<0.05).Conclusion:Dexmedetomidine is more effective than Propofol in epidural anesthesia.It not only has good sedative and analgesic effects,but also helps to avoid other reactions.

【Key words】 Epidural anesthesia; Propofol; Dexmedetomidine; Ramsay sedation score

First-authors address:Maternal and Child Health Hospital of Fang County,Fang County 442100,China

对于采取硬膜外麻醉的妇科手术患者而言,手术期间,极易产生负面情绪,包括焦虑、恐惧、紧张等,而且大部分存在相对严重的应激反应[1]。所以,予以硬膜外麻醉妇科手术患者镇静药物,确保各项生命指征平稳尤为重要[2]。右美托咪定是常见受体激动剂之一,其属于新型的高选择性α2肾上腺能受体激动剂,其镇静、镇痛效果明显,而且具有较强的抗交感作用[3],此外,其不会对呼吸抑制,容易唤醒。丙泊酚是一种短效麻醉药物,同样具有一定镇痛、镇静效果[4],但是两者存在明显差异。基于此,本次研究针对笔者所在医院2018年1-12月接收的70例采取妇科手术治疗患者分别行右美托咪定与丙泊酚麻醉,对效果进行分析,具体报道如下。

1 资料与方法

1.1 一般资料

选取笔者所在医院2018年1-12月接收的采取妇科手术治疗的70例患者为研究对象,随机分为两组,A组35例,年龄22~58岁,平均(42.51±3.26)岁;B组35例,年龄23~87岁,平均(42.39±3.19)岁。两组……

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