蔡芳

【摘要】 目的：探究组织CXC型趋化因子表达在子宫内膜异位症中的变化情况。方法：选取2016年6月-2018年11月笔者所在医院收治的79例子宫内膜异位症患者为观察组，同时期的79例健康妇女为对照组。比较两组的组织CXC型趋化因子表达情况，同时比较观察组中不同分期与分类子宫内膜异位症患者的CXC型趋化因子表达情况。结果：观察组的组织CXCL-12、CXCR1及CXCR2表达均高于对照组，组织CXCL-14表达低于对照组，且观察组中不同分期子宫内膜异位症患者的上述组织CXC型趋化因子表达比较，差异有统计学意义（P<0.05），不同分类子宫内膜异位症患者的表达比较，差异无统计学意义（P>0.05）。结论：组织CXC型趋化因子在子宫内膜异位症患者中呈现异常表达的状态，且对于疾病的分期具有指导作用。

【关键词】 组织; CXC型趋化因子; 子宫内膜异位症; 疾病分期

doi：10.14033/j.cnki.cfmr.2019.27.033 文献标识码 B 文章编号 1674-6805（2019）27-00-02

Study on the Change of Tissue Type CXC Chemokines Expression in the Patients with Endometriosis/CAI Fang.//Chinese and Foreign Medical Research，2019，17（27）：-78

【Abstract】 Objective：To investigate the change of tissue type CXC chemokines expression in the patients with endometriosis.Method：A total of 79 patients with endometriosis from June 2016 to November 2018 were chosen as the observation group，79 healthy women at the same time were chosen as the control group.Then the tissue type CXC chemokines expression situation of two groups were compared，and the type CXC chemokines expression situation of observation group with different stages and types of endometriosis were compared too.Result：The tissue CXCL-12，CXCR1 and CXCR2 expression of observation group were higher than those of control group，the tissue CXCL-14 expression was lower than that of control group，and tissue type CXC chemokines expression of observation group with different stages of endometriosis were compared，the differences were all statistically significant（P<0.05）.The expression of observation group with different types of endometriosis were compared，the differences were not statistically significant（P>0.05）.Conclusion：The tissue type CXC chemokines expression in the patients with endometriosis show abnormal expression state，and it has a guiding role for the stages of diseases.

【Key words】 Tissue; CXC chemokines; Endometriosis; Disease stages

First-authors address：Hospital Directly under Hubei Province，Wuhan 430000，China

子宮内膜异位症是妇科常见病，患者普遍表现出疼痛、不孕等情况，而这也是本病患者就诊的主要原因。与子宫异位内膜相关的研究显示，本病患者的病灶具有侵袭性，同时趋化因子则参与到多类指标，包括细胞的趋化反应过程中，因此趋化因子在子宫内膜异位症患者中的表达变化研究也极为必要[1-2]。本研究就组织CXC型趋化因子表达在子宫内膜异位症中的变化情况进行观察，探究结果报道如下。

1 资料与方法

1.1 一般资料

选取2016年6月-2018年11月笔者所在医院收治的79例子宫内膜异位症患者为观察组，同时期的79例健康妇女为对照组。纳入标准：20～60岁者;符合子宫内膜异位症诊断标准者。排除标准：合并子宫疾病;合并其他妇科疾病;6个月激素治疗史者。……