陈婷 陈金剑

【摘要】 目的：分析DNA倍体分析和尿脱落细胞学检查在尿路上皮癌诊断中的应用。方法：选择笔者所在医院2014年3月-2018年12月收治的52例尿路上皮癌患者纳入观察组，另取52例血尿患者纳入对照组，两组均接受DNA倍体分析和尿脱落细胞学检查。结果：观察组尿脱落细胞学检查阳性率为94.23%，高于对照组的11.54%;观察组DNA倍体分析阳性率为98.08%，高于对照组的7.69%，差异有统计学意义（P<0.05）。DNA倍体分析诊断膀胱癌准确率为97.67%，诊断上尿路上皮癌准确率为100%;尿脱落细胞学检查诊断膀胱癌准确率为95.35%，诊断上尿路上皮癌准确率为88.89%。两种诊断方法诊断准确率比较差异无统计学意义（P>0.05）。结论：DNA倍体分析、尿脱落细胞学检查均可为尿路上皮癌的诊断提供支持。

【關键词】 DNA倍体分析; 尿脱落细胞学检查; 尿路上皮癌

doi：10.14033/j.cnki.cfmr.2019.27.032 文献标识码 B 文章编号 1674-6805（2019）27-00-03

Clinical Value of DNA Ploidy Analysis and Urinary Exfoliative Cytology in Urothelial Carcinoma/CHEN Ting，CHEN Jinjian.//Chinese and Foreign Medical Research，2019，17（27）：74-76

【Abstract】 Objective：To analyze the application of DNA ploidy analysis and urinary exfoliation cytology in the diagnosis of urothelial carcinoma.Method：A total of 52 patients with urothelial cancer admitted to our hospital from March 2014 to December 2018 were enrolled in the observation group，and 52 patients with hematuria were enrolled in the control group.Both groups received DNA ploidy analysis and cytological examination of urinary exfoliation.Result：The positive rate of urine exfoliative cytology in the observation group was 94.23%，which was higher than 11.54% in the control group，and the positive rate of DNA ploidy analysis in the observation group was 98.08%，which was significantly higher than 7.69% in the control group，the differences were statistically significant（P<0.05）.The accuracy of DNA ploidy in the diagnosis of bladder cancer was 97.67%，and the accuracy of the diagnosis of upper urothelial carcinoma was 100%，the accuracy of urine exfoliative cytology in the diagnosis of bladder cancer and epithelial carcinoma was 95.35% and 88.89% respectively，There was no significant difference in diagnostic accuracy between the two methods（P>0.05）.Conclusion：DNA ploidy analysis and cytological examination of urinary exfoliation can provide support for the diagnosis of urothelial carcinoma.

【Key words】 DNA ploidy analysis; Cytological examination of urinary exfoliation; Urothelial carcinoma

First-authors address：Second Hospital of Longyan City，Longyan 364000，China

作为一类较为常见的泌尿系统恶性肿瘤，尿路上皮癌的发生会对患者的日常生活产生极大影响[1]。早期诊断已经成为临床干预尿路上皮癌的主要方向[2]。从人们对尿路上皮癌诊断的要求来看，无创性、准确性是两项关键要求。DNA倍体分析以流式细胞术为核心，其可通过尿液脱落细胞中DNA倍体的变化规律，判断其合并恶性肿瘤的风险[3]。尿脱落细胞学检查则通过光镜下鉴别细胞类型的形式，为肿瘤的识别提供支持。为验证上述两组诊断方法的价值，本研究主要针对104例受检者进行分析，具体如下。

1 资料与方法

1.1 一般资料

选择笔者所在医院2014年3月-2018年12月收治的52例经术后病理确诊的尿路上皮癌患者纳入观察组。纳入标准：符合尿路上皮癌诊断标准。排除标准：（1）不配合者;（2）伴精神疾病者。另取同期于笔者所在医院接受治疗的52例血尿患者纳入对照组。……