李晓迪

【摘要】 目的：研究参附注射液治療冠心病慢性心力衰竭的效果。方法：根据随机数表法将笔者所在医院2016年11月-2017年11月诊治的80例冠心病慢性心力衰竭患者分为观察组与对照组，各40例，对照组给予常规治疗，观察组在对照组的基础上给予参附注射液治疗。治疗3个月后评价疗效及安全性，并测定治疗前后两组患者脑钠肽（BNP）值、左室射血分数（LVEF）、左室舒张末期直径（LVDd）的变化。结果：观察组治疗总有效率为95.00%，显著高于对照组的75.00%，差异有统计学意义（P<0.05）;两组治疗后BNP、LVDd水平均明显下降，LVEF明显上升，且观察组治疗后下降或上升幅度明显大于对照组，差异均有统计学意义（P<0.05）;两组不良反应发生率比较，差异无统计学意义（P>0.05）。

结论：参附注射液治可以治疗冠心病慢性心力衰竭，改善患者心功能，安全且有效。

【关键词】 参附注射液 冠心病 慢性心力衰竭

doi：10.14033/j.cnki.cfmr.2019.28.066 文献标识码 B 文章编号 1674-6805（2019）28-0-02

Effects of Shenfu Injection on Coronary Heart Disease with Chronic Heart Failure/LI Xiaodi. //Chinese and Foreign Medical Research， 2019， 17（28）： -157

[Abstract] Objective： To study the effects of Shenfu Injection on coronary heart disease with chronic heart failure. Method： A total of 80 patients with coronary heart disease and chronic heart failure were diagnosed and treated in our hospital from November 2016 to November 2017. They were divided into observation group and control group according to the random number table method， with 40 cases in each group. The control group was given routine treatment， and the observation group was given Shenfu Injection on the basis of control group. Efficacy and safety were evaluated after 3 months of treatment， and changes of brain natriuretic peptide （BNP）， left ventricular ejection fraction （LVEF） and left ventricular end-diastolic diameter （LVDd） were measured before and after treatment. Result： The total effective rate of treatment in observation group was 95.00%， significantly higher than 75.00% in control group， the difference was statistically significant （P<0.05）. The levels of BNP and LVDd in the two groups were decreased significantly after treatment while the LVEF was increased significantly， and the decreases or increase in observation group after treatment were significantly greater than those in control group， the differences were statistically significant （P<0.05）. There was no significant difference in the incidence rate of adverse reactions between the two groups （P>0.05）. Conclusion： Shenfu Injection can treat coronary heart disease with chronic heart failure， and improve cardiac function. It is safe and effective.

[Key words] Shenfu Injection Coronary heart disease Chronic heart failure

First-authors address： Xishui County Traditional Chinese Medicine Hospital， Xishui 438200， China

冠心病是冠状动脉血管的硬化和病变而引起的心肌缺血、缺氧或者坏死有关，属于心脏病的一种[1]。心力衰竭是冠心病的末期症状，是严重危害人体身心健康的疾病。随着科技的发展，人类对于心力衰竭发病机制的逐步了解，血管紧张素转化酶抑制剂（ACEI）及β受体阻滞剂的应用改善了心力衰竭患者的心功能症状[2]。近年来，已有研究证实，参附注射液具有改善心肌缺氧、调节神经内分泌的作用，可用于治疗心力衰竭[3]。本研究致力于探讨参附注射液治疗冠心病慢性心力衰竭的效果，现报告如下。

1 资料与方法

1.1 一般资料

选择笔者所在医院2016年11月-2017年11月诊治的冠心病慢性心力衰竭患者80例。纳入标准：（1）符合冠心病和慢性心力衰竭诊断标准[4];（2）年龄50～75岁，病程1～7年;（3）NYHA心功能分级Ⅱ～Ⅳ级。……