李红忠

【摘要】 目的：伴睡眠障礙焦虑症老年患者应用米氮平与重复经颅磁刺激联合治疗的效果及心理状态与睡眠指标分析。方法：选取2017年12月-2018年12月笔者所在医院诊治的80例伴睡眠障碍焦虑症老年患者，按照随机数字表法将其分为两组，每组40例。对照组给予米氮平治疗，研究组给予米氮平与重复经颅磁刺激联合方案治疗。比较两组临床效果、睡眠指标及心理状态。结果：治疗后，研究组治疗总有效率为92.50%，高于对照组的72.50%，差异有统计学意义（P<0.05）。研究组治疗后睡眠时间评分（0.86±0.23）分，入睡时间评分（0.91±0.36）分，睡眠质量评分（0.89±0.29）分，

睡眠效率评分（0.83±0.25）分，睡眠障碍评分（1.02±0.18）分，均低于对照组，差异有统计学意义（P<0.01）。研究组治疗后SAS评分（32.23±5.46）分，SDS评分（34.03±5.67）分，均低于对照组，差异有统计学意义（P<0.01）。结论：伴睡眠障碍焦虑症老年患者应用米氮平与重复经颅磁刺激联合治疗，能提高治疗效果，改善患者睡眠质量及心理状态，具临床应用价值。

【关键词】 睡眠障碍; 焦虑症; 米氮平; 重复经颅磁刺激; 心理; 睡眠指标

doi：10.14033/j.cnki.cfmr.2019.27.013 文献标识码 B 文章编号 1674-6805（2019）27-00-03

Clinical Efficacy，Psychological Status and Sleep Indicators Analysis of Mirtazapine Combined with Repetitive Transcranial Magnetic Stimulation in the Treatment of Elderly Anxiety Disorder with Sleep Disorders/LI Hongzhong.//Chinese and Foreign Medical Research，2019，17（27）：-31

【Abstract】 Objective：To analyze the effect，psychological status and sleep indicators of Mirtazapine combined with repetitive transcranial magnetic stimulation in elderly patients with sleep disorders and anxiety disorders.Method：A total of 80 elderly patients with sleep disorders and anxiety disorders treated in our hospital from December 2017 to December 2018 were selected.The patients were divided into two groups according to the random number table method，with 40 cases in each group.The control group was given Mirtazapine.The study group was given Mirtazapine combined with repetitive transcranial magnetic stimulation.The clinical effect，sleep indicators and psychological state of the two groups were compared.Result：After treatment，the total effective rate of the study group was 92.50%，which was lower than 72.50% of the control group，the difference was statistically significant（P<0.05）.After treatment，the scores of sleep time （0.86±0.23）points，sleep latency （0.91±0.36）points，sleep quality （0.89±0.29）points，and sleep efficiency （0.83±0.25）points and sleep disturbance （1.02±0.18）points in the study group were all lower than those in the control group，and the differences were statistically significant（P<0.01）.After treatment，the scores of SAS （32.23±5.46）points，SDS （34.03±5.67）points in the study group were lower than those in the control group，and the differences were statistically significant（P<0.01）.Conclusion：The combination of Mirtazapine combined with repetitive transcranial magnetic stimulation in elderly patients with sleep disorder and anxiety disorders can improve the efficacy，improve the sleep quality and psychological state of patients，which has clinical application value.

【Key words】 Sleep disorders; Anxiety disorders; Mirtazapine; Repeated transcranial magnetic stimulation; Psychological; Sleep indicators

First-authors address：Wudong Hospital of Wuhan City，Wuhan 430084，China

焦虑症（anxiety）又称焦虑神经症，属于神经症疾病中最常见的一种，主要临床表现为焦虑情绪的体验，没有明确对象的担心、紧张、不安、手抖、心悸与运动不安等，影响患者正常生活质量[1]。而睡眠障碍为焦虑症疾病主要并发症，会进一步影响患者睡眠质量。对伴睡眠障碍焦虑症老年患者，临床通常采用药物方案[2-3]，为进一步提高临床效果，本研究选取2017年12月-2018年12月笔者所在医院诊治伴睡眠障碍焦虑症老年患者40例，对应用米氮平与重复经颅磁刺激联合治疗的效果进行分析，具体如下报告。

1 资料与方法

1.1 一般资料

选取2017年12月-2018年12月笔者所在医院诊治80例伴睡眠障碍焦虑症老年患者，纳入标准：确诊为伴睡眠障碍焦虑症，年龄≥60岁，资料完整，主动配合。排除标准：服用其他药，恶性肿瘤者，严重肝肾病，其他精神心理病，妊娠期患者，中途退出者。……