阮俊豪

【摘要】 目的：探討局部放疗联合CHOP方案化疗治疗中晚期非霍奇金淋巴瘤（NHL）的效果及安全性。方法：招募2012年2月-2013年2月笔者所在医院住院治疗的90例中晚期NHL患者为研究对象。采用随机分组信件法将受试者分为观察组和对照组，每组45例。对照组采用CHOP方案化疗，观察组在CHOP化疗后采用原始受累淋巴结区放疗。随访3年，比较两组1年生存率和3年生存率、不良反应（胃肠反应、白细胞降低、脱发及心电图）发生情况及治疗有效率。结果：观察组治疗有效率明显高于对照组，差异有统计学意义（P<0.05）。观察组1年生存率和3年生存率均明显高于对照组，差异均有统计学意义（P<0.05）。两组Ⅲ～Ⅳ级胃肠反应、白细胞降低、脱发及心电图改变发生率对比，差异均无统计学意义（P>0.05）。结论：局部放疗联合CHOP方案化疗可以提高中晚期NHL患者近远期疗效，安全性较高，值得临床推广。

【关键词】 放射治疗; CHOP化疗方案; 中晚期非霍奇金淋巴瘤; 安全性

doi：10.14033/j.cnki.cfmr.2019.27.006 文献标识码 A 文章编号 1674-6805（2019）27-00-03

Efficacy and Safety of Local Radiotherapy Combined with CHOP Chemotherapy in the Treatment of Advanced Non-Hodgkin Lymphoma/RUAN Junhao.//Chinese and Foreign Medical Research，2019，17（27）：-15

【Abstract】 Objective：To evaluate the efficacy and safety of local radiotherapy combined with CHOP chemotherapy in the treatment of advanced non-Hodgkin lymphoma（NHL）.Method：From February 2012 to February 2013，a total of 90 patients with advanced NHL who were hospitalized in the authors hospital were enrolled.Patients were divided into the observation group and the control group by randomized letter method，with 45 cases in each group.The control group received CHOP chemotherapy，and the observation group received radiotherapy in the original affected lymph node area after CHOP chemotherapy.After 3 years of follow-up，the 1-year survival rate and 3-year survival rate，the adverse reactions（gastrointestinal reaction，leukopenia，alopecia and electrocardiogram） and the treatment effectiveness were compared between the two groups.Result：The treatment efficiency of the observation group was significantly higher than that of the control group，and the difference was statistically significant（P<0.05）.The 1-year survival rate and 3-year survival rate of the observation group were significantly higher than that of the control group，and the differences were statistically significant（P<0.05）.The incidence of Ⅲ-Ⅳ gastrointestinal reaction，leukopenia，alopecia and electrocardiogram change were compared between the two groups，and the differences were not statistically significant（P>0.05）.Conclusion：Local radiotherapy combined with CHOP chemotherapy can improve the short and long term efficacy of advanced NHL，and it is safe and worthy of clinical promotion.

【Key words】 Radiation therapy; CHOP chemotherapy regimen; Advanced non-Hodgkin lymphoma; Safety

First-authors address：Nanping First Hospital Affiliated to Fujian Medical University，Nanping 353000，China

淋巴瘤大体可分为霍奇金淋巴瘤和非霍奇金淋巴瘤（non-Hodgkin lymphoma，NHL）两类。在美国，40%以上的淋巴癌是霍奇金淋巴瘤，在我国90%以上是霍奇金淋巴瘤。近十年来，NHL发生率急速增加，已在癌症死亡率排名榜上占据第九位[1]。对于侵袭性NHL，必须给予积极的化学治疗，如CHOP合并疗法是传统的标准治疗方式[2]。新近研究显示，合并化疗及局部放射疗法较单独使用化学治疗可以延长中晚期NHL患者存活时间，而不增加治疗的毒性[3]。本研究旨在探讨局部放疗联合CHOP方案化疗治疗中晚期NHL的效果及安全性，为今后治疗方案制定提供临床依据，具体报道如下。

1 资料与方法

1.1 一般资料

招募2012年2月-2013年2月笔者所在医院住院治疗的90例中晚期NHL患者为研究对象。……