李少杰 陈喜彬 石秀茹

【摘要】 目的：观察醒脑静注射液辅助治疗急性缺血性脑卒中患者的效果及对患者神经功能、生活活动能力和炎症细胞因子的影响。方法：以2018年1月-2019年1月笔者所在医院神经内科、神经介入科、EICU收治的急性缺血性脑卒中患者80例为研究对象，将其随机分为对照组（40例）和治疗组（40例）。对照组给予常规治疗，治疗组在此基础上加用醒脑静注射液治疗。比较两组临床疗效、神经功能、生活活动能力、炎症因子水平及不良反应發生情况。结果：治疗组治疗总有效率明显高于对照组，差异有统计学意义（P<0.05）。治疗前，两组NIHSS、ADL评分比较，差异无统计学意义（P>0.05）;治疗后，治疗组NIHSS评分低于对照组，ADL评分高于对照组，差异有统计学意义（P<0.05）。治疗前两组TNF-α、IL-6水平比较差异无统计学意义（P>0.05）;治疗后，治疗组TNF-α、IL-6水平均低于对照组，差异有统计学意义（P<0.05）。治疗组不良反应发生率低于对照组，差异有统计学意义（P<0.05）。结论：醒脑静注射液在急性缺血性脑卒中辅助治疗中能有效改善患者神经功能和炎症反应水平，从而提高患者生活质量，且不良反应发生率低。

【关键词】 醒脑静注射液; 神经功能; 急性缺血性脑卒中; 炎症因子; 生活活动能力

doi：10.14033/j.cnki.cfmr.2019.27.005 文献标识码 A 文章编号 1674-6805（2019）27-00-03

Effect of Xingnaojing Injection on Patients with Acute Ischemic Stroke and Its Effect on Neurological Function，Activity of Life and Inflammatory Cytokines/LI Shaojie，CHEN Xibin，SHI Xiuru.//Chinese and Foreign Medical Research，2019，17（27）：10-12

【Abstract】 Objective：To observe the effect of Xingnaojing Injection on patients with acute ischemic stroke and its effect on neurological function，activity of life and inflammatory cytokines.Method：A total of 80 patients with acute ischemic stroke admitted in the department of neurology，department of neurological interventional therapy and EICU of our hospital from January 2018 to January 2019 were selected as research objects and randomly divided into the control group（40 cases） and the treatment group（40 cases）.The control group was given routine treatment，and the treatment group was given Xingnaojing Injection on this basis.The clinical efficacy，neurological function，activity of life，inflammatory factors and adverse reactions were compared between the two groups.Result：The total effective rate of the treatment group was significantly higher than that of the control group，and the difference was statistically significant（P<0.05）.Before treatment，there were no significant differences in NIHSS and ADL scores between the two groups（P>0.05）.After treatment，the NIHSS score in the treatment group was lower than that in the control group，and ADL score was higher than that in the control group，the differences were statistically significant（P<0.05）.There were no significant differences in TNF-αand IL-6 levels between the two groups before treatment（P>0.05）.After treatment，TNF-α and IL-6 levels in the treatment group were lower than those in the control group，the differences were statistically significant（P<0.05）.The incidence of adverse reactions in the treatment group was lower than that in the control group，the difference was statistically significant（P<0.05）.Conclusion：Xingnaojing Injection can effectively improve the neurological function and inflammatory reaction level of patients with acute ischemic stroke in the adjuvant treatment，thereby improving the quality of life of patients，and the incidence of adverse reactions is low.

【Key words】 Xingnaojing Injection; Neurological function; Acute ischemic stroke; Inflammatory factors; Activity of life

First-authors address：Fifth Affiliated Hospital of Sun Yat-sen University，Zhuhai 519000，China

急性缺血性卒中（cerebral ischemic stroke，CIS）又称急性脑梗死，是我国常见的卒中类型[1]。目前，临床上主要通过药物（如尿激酶和纤溶酶原激活剂）溶栓治疗来改善脑循环。相关研究显示，溶栓后血液的再次灌注将产生大量氧自由基，难免对脑细胞造成二次损伤[2]。因此，如何增强疗效，减少缺血后再灌注损伤已成为CIS早期治疗的关键。另有研究认为，醒脑静可通过增强细胞对氧化损伤的耐受力来保护神经细胞功能和减轻炎症反应[3]。基于此，本研究拟运用醒脑静注射液辅助治疗CIS，评估其效果及安全性，并观察其对CIS患者炎症细胞因子、神经功能和生活能力改善的影响，现报道如下。……