伍金花 李慧 付本翠 冯丽娟 王静

【摘要】 目的：分析直腸癌放疗联合口服卡培他滨化疗患者放射性直肠炎灌肠治疗的效果。方法：选取笔者所在医院2018年2月-2019年2月收治的100例直肠癌放疗联合口服卡培他滨化疗后放射性直肠炎患者为研究对象，将其随机分为对照组和治疗组，各50例。对照组采用康复新液+地塞米松保留灌肠，治疗组在对照组基础上联合重组人成碱性细胞生长因子保留灌肠。比较两组治疗效果。结果：治疗组治疗总有效率为96.00%，高于对照组的78.00%，差异有统计学意义（P<0.05）。治疗组各临床症状缓解时间均早于对照组，差异有统计学意义（P<0.05）。治疗组患者黏膜损伤程度优于对照组，差异有统计学意义（P<0.05）。治疗组生活质量评分高于对照组，差异有统计学意义（P<0.05）。结论：对直肠癌放疗联合口服他滨化疗放射性直肠炎患者，采用康复新液+地塞米松+重组人成碱性细胞生长因子灌肠治疗，临床效果显著，可有效改善患者临床症状，减少直肠黏膜损伤，提高患者生活质量。

【关键词】 直肠癌 放疗 卡培他滨 放射性直肠炎 灌肠 治疗

doi：10.14033/j.cnki.cfmr.2019.29.018 文献标识码 B 文章编号 1674-6805（2019）29-00-03

[Abstract] Objective： To analyze the effect of radiotherapy combined with oral Capecitabine chemotherapy for rectal cancer patients with radiation proctitis enema. Method： A total of 100 patients with rectal cancer received radiotherapy combined with oral Capecitabine chemotherapy with radiation proctitis were selected as the study objects. They were randomly divided into the control group and the treatment group， with 50 cases in each group. The control group was treated with Kangfuxin Solution and Dexamethasone retention enema， and the treatment group was treated with Recombinant Human Basic Cell Growth Factor retention enema on the basis of the control group. The therapeutic effects of the two groups were compared. Result： The total effective rate in the treatment group was 96.00%， which was higher than 78.00% in the control group， the difference was statistically significant （P<0.05）. The remission time of clinical symptoms in the treatment group were earlier than those in the control group， and the differences were statistically significant （P<0.05）. The degree of mucosal injury in the treatment group was better than that in the control group， and the difference was statistically significant （P<0.05）. The quality of life score of the treatment group was higher than that of the control group， and the difference was statistically significant （P<0.05）. Conclusion： For rectal cancer patients with radiation proctitis treated by radiotherapy combined with oral Capecitabine chemotherapy， Kangfuxin Solution and Dexamethasone and Recombinant Human Basic Cell Growth Factor retention enema has a significant clinical effect， which can effectively improve the clinical symptoms of patients， reduce rectal mucosal injury and improve the quality of life of patients.

[Key words] Rectal cancer Radiotherapy Capecitabine Radiation proctitis Enema Treatment

First-authors address： Affiliated Hospital of Sichuan University of Electronic Science and Technology， Chengdu 610000， China

直肠癌是临床常见的疾病，该疾病往往需要采用放、化疗等治疗方案，但是长期接受放化疗治疗，人体容易受到放射线辐射的影响引起急、慢性放射性直肠炎。临床有关调查显示：部分盆腹腔化疗患者接受放疗后，1个月内会出现不同程度的放射性直肠炎[1]，临床表现以腹痛、腹泻、烦热口渴等为主，致使患者出现营养不良、生活质量下降、治疗依从性下降等。以往放射性直肠炎治疗期间多采用镇痛、抗炎等治疗，但是临床效果并不理想。故近年来临床对放射性直肠炎的治疗效果进行加强研究，并取得一定的成果[2]。本研究探讨了康复新液+地塞米松+重组人成碱性细胞生长因子灌肠治疗放射性直肠炎的效果，现报道如下。

1 资料与方法

1.1 一般资料

选取2018年2月-2019年2月笔者所在医院接收的50例直肠癌放疗联合口服卡培他滨化疗放射性直肠炎患者为研究对象，纳入标准：经临床病理、实验室检查确诊;Karnofsky评分≥60分。……