刘亚丽

[摘要] 目的 分析研究不同剂量米非司酮治疗子宫肌瘤的临床效果。 方法 2016年9月—2018年1月期间，方便选择到该院就诊的88例子宫肌瘤患者，采取数字抓阄的方式进行分组，单号设为对照组（n=44），双号设为实验组（n=44）。对照组，25 mg/d米非司酮治疗，实验组，12.5 mg/d米非司酮治疗，观察临床疗效。结果 数据显示，实验组总有效率为88.6%，对照组为84.1%，差异有统计学意义（χ2=0.859，P=0.354）。比较临床指标，治疗前与治疗后组间差异无统计学意义（P>0.05）。统计不良反应，实验组发生率为6.8%，对照组为15.9%，差异有统计学意义（χ2=4.115，P=0.042）。结论 米非司酮治疗子宫肌瘤，效果显著，相比高剂量，低剂量用药，不良反应少，更安全。

[关键词] 剂量;米非司酮;子宫肌瘤;治疗效果

[中图分类号] R737          [文献标识码] A          [文章编号] 1674-0742（2018）08（c）-0123-03

Effect of Different Doses of Mifepristone on the Treatment of Uterine Fibroids

LIU Ya-li

No. 208 Hospital of Chinese People's Liberation Army， Changchun， Jilin Province， 130062 China

[Abstract] Objective To analyze the clinical effects of different doses of mifepristone in the treatment of uterine fibroids. Methods From September 2016 to January 2018， 88 patients with uterine leiomyoma who were convenient selected for treatment in the hospital were divided into groups by digital grabbing. The single number was set as the control group（n=44） and experimental group （n=44） with 25 mg/d mifepristone treatment and 12.5 mg/d mifepristone treatment， observe the clinical efficacy. Results The data showed that the total effective rate was 88.6% in the experimental group and 84.1% in the control group，the difference was statistically significnat（χ2=0.859， P=0.354）. Compared with clinical indicators， there was no significant difference between pre-treatment and post-treatment groups（P>0.05）. The statistical analysis of adverse reactions occurred in 6.8% in the experimental group and 15.9% in the control group，the difference was statistically significnat（χ2=4.115， P=0.042）. Conclusion Mifepristone is effective in the treatment of uterine fibroids. Compared with high-dose and low-dose drugs， the adverse reactions are less and safer.

[Key words] Dose; Mifepristone; Uterine fibroids; Therapeutic effect

子宮肌瘤（Hysteromyoma）也称子宫纤维瘤、纤维肌瘤，是位于女性生殖器官中的良性肿瘤，发病率高，由子宫平滑肌细胞增生所成[1]。目前，米非司酮是治疗子宫肌瘤的常用药，但关于其用药剂量，学者们看法不一。2016年9月—2018年1月期间，该研究将88例患者分为两组，分别按照12.5 mg/d与25 mg/d的标准用药，观察不同剂量米非司酮应用于子宫肌瘤治疗的效果，现报道如下。

1  资料与方法

1.1  一般资料

方便选择到该院就诊的88例子宫肌瘤患者，采取数字抓阄的方式进行分组，单号设为对照组（n=44），双号设为实验组（n=44）。纳入标准：①符合子宫肌瘤诊断标准，经B超或CT检查，确诊;②年龄20～50岁，女性;③自愿参与研究，签署有知情同意书;④该次研究经医学伦理委员会审核批准。排除标准：①不愿参与研究的患者;②年龄……