杨玉成

[摘要] 目的 比較老年食管癌放化疗结合治疗与单纯放疗治疗的效果与安全性。 方法 方便该院2015年1月—2017年4月间收治的66例老年食管癌患者纳入该次实验，采取随机双盲法将其分为实验组（33例）与对照组（33例），实验组患者采取放化疗联合治疗，对照组患者采取单纯放疗治疗，对比两种治疗方案的效果和安全性。结果 实验组患者治疗总有效率（81.8%）较对照组（57.6%）更高，组间比较差异有统计学意义（χ2=4.591，P=0.032）;治疗后1年内肿瘤局部控制率（57.6%）较对照组（33.3%）更高，组间比较差异有统计学意义（χ2=3.911，P=0.048）;肿瘤复发率（15.2%）较对照组（36.4%）更低，组间比较差异有统计学意义（χ2=4.765，P=0.029）;不良反应发生率（45.5%）较对照组（18.1%）更高，组间比较差异有统计学意义（χ2=17.776，P=0.000）。两组患者治疗后1年内生存率无明显区别，组间比较差异无统计学意义（χ2=2.157，P=0.142）。 结论 放化疗结合治疗较单纯放疗治疗老年食管癌的疗效更佳，安全性也可接受，更适宜临床推广应用。

[关键词] 老年食管癌;放化疗;单纯放疗;治疗效果;安全性

[中图分类号] R5          [文献标识码] A          [文章编号] 1674-0742（2018）08（c）-0084-03

Comparison of Efficacy and Safety of Radiotherapy and Chemotherapy Combined with Radiotherapy for Elderly Patients with Esophageal Cancer

YANG Yu-cheng

Department of Radiotherapy， the First Hospital of Putian， Putian， Fujian Province， 351100 China

[Abstract] Objective To compare the efficacy and safety of radiotherapy and chemotherapy combined with radiotherapy for elderly esophageal cancer. Methods 66 elder patients with esophageal cancer admitted to the hospital were included in this experiment. The convenient selected cases were from January 2015 to April 2017. They were divided into experimental group （33 cases） and control group （33 cases） by random double-blind method. Patients in the experimental group were treated with radiotherapy and chemotherapy， and patients in the control group were treated with radiotherapy alone. The efficacy and safety of the two treatment protocols were compared. Results The total effective rate of treatment in the experimental group （81.8%） was higher than that in the control group （57.6%）. The difference between groups was statistically significant （χ2= 4.591， P=0.032）. The local control rate of the tumor within one year after treatment （57.6%） was higher than that of the control group （33.3%）， the difference between groups was statistically significant（χ2= 3.911， P=0.048）; tumor recurrence rate （15.2%） lower than the control group （36.4%）， the difference between groups was statistically significant（χ2= 4.765， P=0.029）; incidence of adverse reactions （45.5%） was higher than the control group （18.1%）. The difference between groups was statistically significant（χ2=17.776， P=0.000）. There was no significant difference in survival rate between the two groups after one year of treatment. The difference between groups was not statistically significant（χ2=2.157，P=0.142）. Conclusion Radiotherapy and chemotherapy combined with radiotherapy alone is more effective than radiotherapy alone in the treatment of esophageal cancer in the elderly. The safety is also acceptable. It is more suitable for clinical application.

[Key words] Elderly esophageal cancer; Radiotherapy and chemotherapy; Radiotherapy alone; Therapeutic effect; Safety

食管癌是一高发的消化道肿瘤，其发病人群以40岁以上中老年人为主，具有较高的致死率，在确诊后需尽早进行治疗。食管癌在早期无明显症状，多数患者在确诊时已经到了晚期，错过了手术治疗的机会，而必须选择放疗或化疗治疗[1]。该次实验方便选取该院在2015年1月—2017年4月收治的66例老年食管癌患者为研究对象，就放化疗结合治疗与单纯放疗治疗的效果和安全性进行分析、对比，现报道如下。

1  资料与方法