黎华清 陈志生 黎志洲

[摘要]目的 观察阿托伐他汀治疗慢性硬膜下血肿术后残血的效果。方法 选取2015年3月～2017年11月新兴县人民医院及云浮市人民医院收治的56例钻孔引流术（BHID）患者作为研究对象，随机分为两组，每组各28例。对照组采用常规术后治疗方法，观察组在此基础上加用阿托伐他汀。定期随访12周，比较两组患者术后残血量、Markwalder分级和复发情况。结果 观察组术后残血量（第6周、第12周）少于对照组，Markwalder分级（第12周）优于对照组，差异有统计学意义（P<0.05）。结论 阿托伐他汀可减少慢性硬膜下血肿术后残血量，改善脑神经功能，值得临床推广。

[关键词]阿托伐他汀；慢性硬膜下血肿；残血量；治疗效果

[中图分类号] R651.15 [文献标识码] A [文章编号] 1674-4721（2018）9（a）-0088-03

[Abstract] Objective To observe the effect of atorvastatin on the postoperative residual hematoma in patients with chronic subdural hematoma. Methods A total of 56 patients who received burr hole irrigation and drainage （BHID） in the People′s Hospital of Xinxing County and the People′s Hospital of Yunfu City from March 2015 to November 2017 were selected as research subjects. The patients were randomly divided into two groups， with 28 cases in each group. The control group was treated with routine postoperative treatment. The observation group was treated with atorvastatin on the basis of the control group. After 12 weeks of regular follow-up， the postoperative residual hematoma， Markwalder grading and recurrence of the two groups were compared. Results The residual hematoma （6th week， 12th week） of the observation group was less than that in the control group， Markwalder grading （12th week） was superior to the control group， the differences were statistically significant （P<0.05）. Conclusion Atorvastatin can reduce the amount of residual hematoma after chronic subdural hematoma， improve brain function， worthy of clinical promotion.

[Key words] Atorvastatin； Chronic subdural hematoma； Residual Hematoma； Treatment effect

慢性硬膜下血腫（chronic subdural hematoma，CSDH）是指颅内出血血液积聚于硬脑膜下腔，经过3周以上出现症状者，血肿大多广泛覆盖大脑半球的额、顶和颞叶[1-2]。据文献报道，我国CSDH发病率约为1/10万，已成为神经外科的常见病[3-4]。目前针对CSDH的治疗，主要以钻孔引流术（burr hole irrigation and drainage，BHID）为主，尽管该手术可明显缓解颅内高压症状，引流血肿效果较好，但仍会有残血及一定的复发率存在。如何减少残血量和降低术后复发率，已经成为CSDH研究热点之一[5]。本研究旨在探讨阿托伐他汀治疗慢性硬膜下血肿术后残血的临床效果，现报道如下。

1资料与方法

1.1一般资料

本研究经医院医学伦理委员会批准同意，选取2015年3月～2017年11月新兴县人民医院及云浮市人民医院收治的56例BHID患者作为研究对象，平均年龄（69.45±11.11）岁，将患者随机分为两组，观察组28例，男23例，女5例；平均年龄（67.75±10.88）岁。对照组28例，男25例，女3例；平均年龄（71.14±11.07）岁。所有患者均知情同意本研究。……