廖桂雅 龙顺钦 邓宏 李秋萍 黄锦鹏 甘紫胭 毕嘉仪 刘宇

[摘要] 目的 研究旋極针法对含铂化疗方案治疗恶性肿瘤减毒作用的临床效果。 方法 选择2017年7～12月在广东省中医院接受治疗的59例恶性肿瘤患者作为研究对象。根据随机数字表法将其随机分为观察组（29例）和对照组（30例）。两组均予常规含铂治疗方案，共化疗2个周期，观察组在化疗期间予旋极针法治疗10 d。对比两组化疗前后的细胞免疫功能、生存质量评分、骨髓抑制和消化道反应情况。 结果 治疗后观察组CD3+、CD4+、CD8+及CD4+/CD8+水平均高于治疗前，对照组CD3+及CD4+水平高于治疗前，差异均有统计学意义（均P < 0.05）。治疗后观察组CD3+、CD4+、CD8+及CD4+/CD8+水平均高于对照组，差异均有统计学意义（均P < 0.05）。观察组生命质量测定量表EORTC QLQ-C30中总健康评分明显高于对照组，恶心呕吐、疼痛、食欲评分明显低于对照组，差异均有统计学意义（均P < 0.05）。观察组骨髓抑制和消化道反应发生率明显低于对照组，差异均有统计学意义（均P < 0.05）。 结论 旋极针法联合含铂化疗方案可以减轻恶性肿瘤患者毒副作用，提高免疫功能及生存质量，临床上可考虑将此治疗方案进行推广。

[关键词] 旋极针法；含铂化疗方案；恶性肿瘤；减毒作用

[中图分类号] R246 [文献标识码] A [文章编号] 1673-7210（2018）07（a）-0117-04

Clinical study of Xuanji acupuncture method on attenuation effects of Platinum chemotherapy regimen in the treatment of malignant tumor

LIAO Guiya1，2 LONG Shunqin1，2 DENG Hong1，2 LI Qiuping1，2 HUANG Jinpeng1，2 GAN Ziyan1，2 BI Jiayi1，2 LIU Yu1

1.The Second Clinical College， Guangzhou University of Chinese Medicine， Guangdong Province， Guangzhou 510120， China； 2.Department of Oncology， Guangdong Provincial Hospital of Traditional Chinese Medicine， Guangdong Province， Guangzhou 510370， China

[Abstract] Objective To study the clinical effect of Xuanji acupuncture method on attenuation effects of Platinum chemotherapy regimen in the treatment of malignant tumor. Methods Fifty-nine patients with malignant tumor treated in Guangdong Provincial Hospital of Traditional Chinese Medicine from July to December 2017 were selected and randomly divided into observation group （29 cases） and control group （30 cases） according to the random number table method. Both groups were treated with Platinum chemotherapy regimen routinely for 2 courses， while the observation group was treated with Xuanji acupuncture during chemotherapy for 10 days. The cellular immune function， quality of life， bone marrow suppression conditions and digestive tract reactions before and after treatment between the two groups were compared. Results After treatment， the levels of CD3+， CD4+， CD8+ and CD4+/CD8+ in the observation group were significantly higher than those before treatment； the levels of CD3+ and CD4+ in the control group were significantly higher than those before treatment （all P < 0.05）. After treatment， the levels of CD3+， CD4+， CD8+ and CD4+/CD8+ in the observation group were significantly higher than those of the control group （P < 0.05）. In European organization for research and treatment of cancer （EORTC） QLQ-C30， the score of total health in the observation group was significantly higher than that of the control group， while the scores of nausea， vomiting， pain and appetite were significantly lower than those of the control group （all P < 0.05）. The incidence of bone marrow suppression and digestive tract reaction in the observation group were significantly lower than those in the control group （all P < 0.05）. Conclusion Xuanji acupuncture method combined with Platinum chemotherapy regimen can reduce toxicity function of patients with malignant tumor， and it can improve the immune function and quality of life， which may deserve for clinical promotion.

[Key words] Xuanji acupuncture method； Platinum chemotherapy regimen； Malignant tumor； Attenuation effects

伴随当前分子生物学的发展，恶性肿瘤的治疗方式也呈现了多样化，但化疗依旧是治疗中晚期恶性肿瘤的重要手段。据统计，我国当前临床上的化疗方案当中，使用含铂药物的比例占70%～80%[1-2]。这是由于铂类药物存在较好的抗癌活性和比较宽的抗癌谱等特点，但需指出，由于铂类药物在化疗过程中会引起消化道和肾毒性等毒副作用，在一定程度上限制了此类药物的广泛应用。旋极针法是我国著名的针灸学家——左常波教授创立的，此法立足在先后天的脾肾两本，也是立极针法（含支沟和太白）及斡旋针法（含右心门和右足三里，以及左太冲和左太白）等经典针法组合变化而来[3-4]。由于旋极针法能够改善患者脾肾亏虚及中气斡旋不利等情况，其对患者的机体免疫及生存质量具有较好的促进作用。……