利燕英 毛爱萍

【摘要】 目的：研究布地奈德差异性剂量对支气管哮喘（BA）患儿的疗效和肺部功能的影响分析。方法：选择2014年3月-2016年9月在本院进行治疗的98例支气管哮喘患儿为研究对象，按照随机数字表法将其分为观察组和对照组，每组49例。对照组在常规治疗的基础上给予布地奈德混悬液0.5 mg/次进行雾化吸入治疗，观察组在常规治疗的基础上给予布地奈德混悬液1.0 mg/次治疗。分别记录两组患儿治疗7 d后哮喘症状评分和肺功能指标即第1秒用力呼气量（forced expiratory volume，FEV1）、最高呼气流速（peak expiratory flow，PEF）占预计值的百分比，以及第1秒用力呼气量占用力肺活量的比值（FEV1/FVC）。结果：治疗前观察组哮喘症状评分为（1.93±0.34）分，对照组为（1.91±0.30）分，两组哮喘症状评分比较，差异无统计学的意义（t=0.309，P=0.758）。治療后，观察组哮喘症状评分为（0.64±0.11）分，对照组为（0.98±0.20）分，观察组哮喘症状评分明显低于对照组，差异有统计学意义（t=10.427，P=0.000）。治疗后，观察组的PEF占预计值的百分比值为（81.17±3.92）%，对照组为（75.33±3.49）%，观察组的PEF占预计值的百分比值明显高于对照组，差异有统计学的意义（t=7.789，P=0.000）。治疗后，观察组FEV1有明显的升高，对照组FEV1无明显差异，即观察组FEV1明显高于对照组，且FEV1/FVC值明显高于对照组，差异均有统计学的意义（P<0.05）。结论：布地奈德差异性剂量对支气管哮喘患儿和肺功能治疗有明显差异，在常规治疗的基础上使用1.0 mg/次布地奈德混悬液治疗支气管哮喘患儿，可以显著地减轻其哮喘症状和改善肺功能。

【关键词】 差异性； 布地奈德； 支气管哮喘； 肺功能； 指标

【Abstract】 Objective：To study the effect of different doses of Budesonide on efficacy and pulmonary function of children with bronchial asthma （BA）.Method：A total of 98 children with BA who were treated in our hospital from March 2014 to September 2016 were selected as study objects.According to the random number table method，they were divided into observation group and control group，49 cases in each group.The control group was treated with Budesonide suspension for 0.5 mg/times atomization inhalation treatment on the basis of routine treatment.The observation group was treated with Budesonide suspension for 1.0 mg/times on the basis of routine treatment.After treatment 7 d，the asthmatic symptom scores and forced expiratory volume at the 1st second（FEV1），the percentage of the peak expiratory flow （PEF） to the predicted value and FEV1/FVC value of pulmonary function indexes were recorded in the two groups.Result：Before treatment，the score of asthma symptoms in the observation group was（1.93±0.34）score and in the control group was （1.91±0.30） score，there was no significant difference in asthmatic symptom scores between the two groups （t=0.309，P=0.758）.After treatment，the score of asthma symptoms in the observation group was （0.64±0.11）score，and in the control group was（0.98±0.20）score，the observation group was higher than that of the control group，the difference was statistically significant （t=10.427，P=0.000）.After treatment，the percentage of PEF to the predicted value in the observation group was （81.17±3.92）% and in the control group was （75.33±3.49）%，the percentage of PEF to the predicted value in the observation group was significantly higher than that of the control group，the difference was statistically significant（t=7.789，P=0.000）.After treatment，the FEV1 in the observation group was significantly increased，but the FEV1 in the control group was not significantly different，the FEV1 in the observation group was significantly higher than that in the control group，and the FEV1/FVC value of the control group was significantly higher than that of the control group，the differences were statistically significant （P<0.05）.Conclusion：Difference doses of Budesonide has obvious difference in the treatment of children with BA and pulmonary function.On the basis of routine treatment，the use of 1.0 mg Budesonide suspension in the treatment of BA children can significantly reduce the symptoms of asthma and improve the pulmonary function.

【Key words】 Difference； Budesonide； Bronchial asthma； Pulmonary function； Index

First-authors address：Yuancheng Peoples Hospital of Heyuan，Heyuan 517000，China

doi：10.3969/j.issn.1674-4985.2018.18.035

支气管哮喘（bronchial asthma，BA）是目前临床上的一种常见疾病、多发疾病，支气管哮喘是一种以慢性气道炎症和气道高反应性为特征的异质性疾病，以反复发作的喘息、咳嗽、气促、胸闷为主要临床表现。常在夜间和/或清晨发作或加剧。……