蒋黎　严熙

【摘要】 目的：觀察及研究瑞格列奈与二甲双胍治疗继发性失效2型糖尿病的临床疗效。方法：选取2016年10月-2017年6月笔者所在医院收治的86例继发性失效2型糖尿病患者，随机分为对照组（采用二甲双胍治疗）和观察组（采用瑞格列奈与二甲双胍联合治疗），每组43例，比较两组的临床疗效（总有效率）、治疗前后的血糖、糖化血红蛋白及血清脂联素、瘦素水平。结果：观察组的临床治疗总有效率显著高于对照组，比较差异有统计学意义（P<0.05）；治疗前两组患者的空腹及餐后2 h血糖、糖化血红蛋白、血清脂联素、瘦素水平比较，差异均无统计学意义（P>0.05）；治疗后6、12周时，观察组的空腹及餐后2 h血糖、糖化血红蛋白、血清瘦素水平均显著低于对照组，血清脂联素水平均显著高于对照组，比较差异均有统计学意义（P<0.05）。结论：瑞格列奈与二甲双胍联合治疗继发性失效2型糖尿病的临床效果较好，且对继发性失效糖尿病相关指标有较好的调控作用，临床应用价值较高。

【关键词】 瑞格列奈； 二甲双胍； 继发性失效2型糖尿病； 临床疗效

doi：10.14033/j.cnki.cfmr.2018.18.011 文献标识码 B 文章编号 1674-6805（2018）18-00-03

Observation on the Clinical Effect of Repaglinide and Metformin in the Treatment of Type 2 Diabetes with Secondary Failure/JIANG Li，YAN Xi.//Chinese and Foreign Medical Research，2018，16（18）：-29

【Abstract】 Objective：To observe and study the clinical effect of Repaglinide and Metformin in the treatment of type 2 diabetes with secondary failure.Method：From October 2016 to June 2017，86 patients with type 2 diabetes with secondary failure in the authors hospital were randomly divided into control group（treated with Metformin）and observation group（combined with Repaglinide and Metformin），43 cases in each group.The clinical effect（total effective rate），blood glucose，glycosylated hemoglobin，serum adiponectin，and leptin levels before and after the treatment were compared between the two groups.Result：The total effective rate of clinical treatment in the observation group was significantly higher than that in the control group，and the difference was statistically significant（P<0.05）.There was no significant difference in fasting and postprandial 2 h blood glucose，glycosylated hemoglobin，serum adiponectin，and leptin levels levels between the two groups before treatment（P>0.05）.At 6 and 12 weeks after treatment，fasting and 2 h postprandial blood glucose，glycosylated hemoglobin，and serum leptin levels were significantly lower in the observation group than in the control group，serum adiponectin levels were significantly higher in the observation group than in the control group，and the differences were statistically significant（P<0.05）.Conclusion：The combined effect of Repaglinide and Metformin in the treatment of type 2 diabetes with secondary failure has a good clinical effect，and has a good regulatory effect on diabetes with secondary failure related indicators，and has higher clinical application value.

【Key words】 Repaglinide； Metformin； Type 2 Diabetes with secondary failure； Clinical effect

First-authors address：Nanchong Maternal and Child Health Care of Family Planning Service Center，Nanchong 637000，China

糖尿病在我国发病率较高，与糖尿病治疗相关的研究显示，磺脲类药物的长时间应用导致的继发性失效糖尿病发生率也有所升高[1-2]，而这导致糖尿病的治疗难度进一步增加。与继发性失效糖尿病相关的研究显示，本类患者普遍存在脂联素及瘦素等指标的异常升高[3]，而上述指标可能参与到其继发性失效的过程中，因此对其调控的需求也较高。本文中笔者就瑞格列奈与二甲双胍治疗继发性失效2型糖尿病的临床疗效进行观察与研究，现将结果进行分析并总结如下。

1 资料与方法

1.1 一般资料

选取2016年10月-2017年6月笔者所在医院诊治的86例继发性失效2型糖尿病患者，纳入标准：年龄≤65岁者；……