冯丽丽 郭涛 刘超

【摘 要】 目的：观察脉管通胶囊联合西药治疗颈动脉粥样硬化斑块的临床疗效。方法：选取120例颈动脉粥样硬化斑块患者随机分为治疗组60例与对照组60例，对照组口服辛伐他汀，治疗组在对照组基础上加服脉管通胶囊；两组均治疗3个月后观察临床疗效，治疗前后分别检测两组患者颈动脉内膜中层厚度（IMT）、血脂变化。结果：治疗后两组颈动脉内膜中层厚度（IMT）变薄、颈动脉粥样硬化斑块临床疗效和血清TC、TG、HDL-C、LDL-C较治疗前有明显好转，两组治疗前后比较差异有统计学意义（P<0.05）。治疗组在治疗后颈动脉内膜中层厚度（IMT）较对照组变薄、颈动脉粥样硬化斑块面积较对照组缩小，血清TC、TG、LDL-C均较对照组改善明显，两组比较差异有统计学意义（P<0.05）。结论：脉管通胶囊联合辛伐他汀可显著增加抗动脉粥样硬化的效果，使粥樣硬化斑块减小，降低颈动脉内膜中层厚度，调节血脂水平，值得临床推广应用。

【关键词】 颈动脉粥样硬化斑块；脉管通胶囊；辛伐他汀；中西医结合

【中图分类号】R543.1+2 【文献标志码】 A 【文章编号】1007-8517（2018）14-0081-04

Abstract：Objective：To observe the clinical effect of Mai Guan Tong Capsule on patients with carotid atherosclerosis.Methods：120 patients with carotid atherosclerosis were randomly divided into the treatment Group（60cases）and the control group（60cases）.The controlled group was given by simvastatin，the treatment group was given Mai Guan Tong Capsule on the basis of the controlled group.The Intima-media- thickness（IMT），TC，TG，HDL-C，LDL-C and clinical syndrome of the patients of two groups before and after treatment were measured.Results：After treatment，IMT was thinning of the two groups，and the serum TC，TG，HDL-C，LDL-C and clinical syndrome were better than that before the treatment，the effect of the two groups before and after treatment had significant difference（P<0.05）.comparing the two groups after treatment，IMT of the treatment group was thinner than that of the controlled group，and the serum TC，TG，LDL-C and clinical syndrome of the treatment group were better than those of the controlled group，there were significant differences between the two groups（P<0.05）.Conclusion：Mai Guan Tong Capsule plays an important role in antiarrhythmia，which could better improve atherosclerosis in combination with simvastatin，Promoting plaque regression，reducing carotid intima-media thickness and Regulating blood lipid levels.Mai Guan Tong Capsule should be worthy of clinical promotion.

Keywords：Carotid Atherosclerotic Plaques；Mai Guan Tong Capsule；Simvastatin；Integrative Medicine

动脉粥样硬化（Atherosclerosis，AS）是由多种因素导致的以进行性动脉管壁受损、炎性细胞浸润、脂质沉积、纤维组织增生为特点，是多种心脑血管疾病的重要病理基础[1]。血脂代谢紊乱是颈动脉粥样硬化斑块形成的主要危险因素，是心血管病及全身动脉粥样硬化疾病的主要病因，其中，冠心病和脑卒中是动脉粥样硬化的常见并发症，也是世界范围内的两大主要死亡原因[2]。颈动脉粥样硬化与心脑血管疾病有明确相关性[3]，可早期提示心脑血管疾病的易患性。因此预防和延缓颈动脉粥样斑块的形成已成为防治心脑血管疾病的热点。临床治疗动脉粥样硬化疾病，常以西医药物为主，如他汀类药物，但整体治疗效果并不理想。近年来，中医药在抗AS治疗中，稳定斑块，甚至消退斑块方面取得了一定的突破。……