单菲菲　陈琴　吕建国

摘 要：目的 探索子宮内膜癌发生的危险因素，以期为子宫内膜癌防治策略的制定提供一定的参考依据。方法 采用基于医院的病例对照研究，以浙江大学医学院附属妇产科医院为研究现场，于2016年3月～12月以经组织病理学确诊为子宫内膜癌的初治患者为病例组，同一时期在本院就诊且无生育要求的良性疾病患者为对照组，通过对30例病例组和31例对照组进行问卷调查，研究可能的疾病危险因素。结果 在校正了研究对象的一般人口学特征、BMI和家族肿瘤史等相关因素后，结果显示是否进行中等强度体力活动和平均每天静坐时间与子宫内膜癌的发生有关（P<0.05），进行中等强度体力活动（OR=0.072，95%CI=0.006～0.860）和平均每天大于6h的静坐时间（OR=0.076，95%CI=0.009～0.651）是子宫内膜癌发生的保护因素。结论 除高年龄等已知的引起子宫内膜癌发生的危险因素外，缺乏中等强度的体力活动也可能是危险因素之一，而较长的静坐时间是否为保护因素还需要进一步的研究来证明。

关键词：子宫内膜癌；危险因素；病例对照研究

中图分类号：R737.33 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.10.019

文章编号：1006-1959（2018）10-0062-03

Case Control Study on the Relationship between Physical Activity and Endometrial Carcinoma

SHAN Fei-fei1，CHEN Qin2，LV Jian-guo2，YANG Jun1，WU Yin-yin1

（1.School of Medicine，Hangzhou Normal University，Hangzhou 310000，Zhejiang，China；

2. the Affiliated Obstetrics and Gynecology Hospital of Zhejiang University Medical College，Hangzhou 310000，Zhejiang，China）

Abstract：Objective To explore the risk factors of endometrial carcinoma and to provide some references for the prevention and treatment of endometrial carcinoma.Methods A hospital-based case-control study was conducted with the affiliated Obstetrics and Gynecology Hospital of Zhejiang University Medical College as the study site，and the patients with endometrial carcinoma diagnosed by histopathology from March 2016 to December 2016 were selected as the case group.In the same period，the patients with benign diseases who had no fertility requirement in our hospital were selected as the control group.The possible risk factors of the disease were investigated by questionnaire survey among 30 cases and 31 cases of control group，to study the possible risk factors for disease.Results After adjusting the general demographic characteristics，BMI and family tumor history of the subjects，the results showed that moderate physical activity and average daily sit-in time were associated with endometrial cancer（P<0.05），moderate intensity physical activity（OR=0.072， 95%CI=0.006～0.860）and the mean sedentary time of more than 6 hours per day was（OR=0.076，95%CI=0.009～0.651），which were the protective factors of endometrial carcinoma.Conclusion In addition to high risk factors such as high age and other known causes of endometrial cancer，lack of moderate physical activity may also be one of the risk factors，and whether a longer sit-in time is a protective factor requires further research to prove.

Key words：Endometrial carcinoma；Risk factors；Case-control studyx

子宫内膜癌（endometrial carcinoma，EC）是原发于子宫内膜的一组上皮性恶性肿瘤，是常见的女性生殖系统肿瘤之一。近年来，其发病率在全球范围内加速上升，从2002年的19.8/10万上升至2008年的28.7/10万，已居发达国家死因排位第10位[1]，严重威胁妇女的生命健康。2015年，美國报道新发子宫内膜癌54870例，死亡10170例[2]。我国的子宫内膜癌发病率也逐年攀升，从2004年的6.51/10万到2008年的9.52/10万，上升了1.5倍[3]。因此，本研究采用病例对照的研究方法，探索子宫内膜癌发生的危险因素，以期为子宫内膜癌防治策略的制定提供一定的参考依据。

1 资料与方法

1.1研究对象 采取病例对照研究，以浙江大学医学院附属妇产科医院为研究现场，研究对象均为浙江省人群。本研究于2016年3月～12月分别收集病例组30例，病例对照组31例。……