杨阳　汪甦　李鑫　朱立东

摘 要：目的 探究青鵬软膏联合地奈德软膏治疗儿童特应性皮炎的临床疗效及对血清炎性因子影响。方法 选取2016年1月～2017年1月在我院治疗的特应性皮炎患儿74例，数字表随机分配法分为实验组和对照组，各37例。实验组采取青鹏软膏联合地奈德软膏治疗，对照组采用地奈德软膏治疗。观察两组患儿临床疗效，治疗前后SCORAD评分，检测患儿血清嗜酸性粒细胞含量，记录副反应发生情况。结果 实验组有效率97.30%，高于对照组72.97%，差异有统计学意义（P<0.05）；治疗后两组各项SCORAD评分低于治疗前，差异有统计学意义（P<0.05）；实验组皮疹、瘙痒和总积分低于对照组，差异有统计学意义（P<0.05）；实验组血清嗜酸性粒细胞含量少于对照组，差异有统计学意义（P<0.05）；两组副反应发生率对比，差异无统计学意义（P>0.05）。结论 青鹏软膏联合地奈德软膏治疗儿童特应性皮炎可有效提高临床疗效，清除炎性因子，且未增加不良反应发生率。

关键词：青鹏软膏；地奈德软膏；特应性皮炎；炎性因子

中图分类号：R751 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.11.041

文章编号：1006-1959（2018）11-0130-03

Clinical Efficacy of Qingpeng Ointment Combined with Desonide Ointment in the Treatment of Atopic Dermatitis in Children

YANG Yang1，WANG Su1，LI Xin1，ZHU Li-dong2

（Department of Dermatology1，Department of Surgery2，Beijing Puren Hospital，Beijing 100062，China）

Abstract：Objective To investigate the clinical effect of Qingpeng ointment combined with desonide ointment on atopic dermatitis in children and its effect on serum inflammatory factors.Methods 74 children with atopic dermatitis treated in our hospital from January 2016 to January 2017 were randomly divided into experimental group（n=37）and control group（n=37）.The experimental group was treated with Qingpeng ointment combined with desonide ointment，while the control group was treated with desonide ointment.The clinical efficacy，SCORAD score，serum eosinophil content and side effects were observed before and after treatment.Results The effective rate was 97.30% in the experimental group and 72.97% in the control group，the difference was statistically significant（P<0.05）.After treatment，the SCORAD scores in the two groups were lower than before treatment，and the difference was statistically significant（P<0.05）.The rash，itching，and total scores in the experimental group were lower than those in the control group，the difference was statistically significant（P<0.05）；the content of serum eosinophils in the experimental group was less than that in the control group，the difference was statistically significant（P<0.05）.There was no significant difference in the incidence of adverse reactions between the two groups（P>0.05）.Conclusion Qingpeng ointment combined with neridide ointment for children with atopic dermatitis can effectively improve the clinical efficacy，eliminate inflammatory factors， and did not increase the incidence of adverse reactions.

Key words：Qingpeng ointment；Desonide ointment；Atopic dermatitis；Inflammatory factors

特应性皮炎（atopic dermatitis，AD）是一种与遗传因素有关的慢性复发性皮肤病，各年龄均可发病，多发于儿童[1]。AD发病机制复杂，与变态反应、免疫调节等有密切联系。临床表现为皮肤呈多形态损伤，急性表现红斑、溃疡、丘疹渗出，妥协丘疹，慢性皮损主要为皮肤苔藓化、痂皮等[2]。AD发病过程中有众多细胞因子参与，可通过检测炎性细胞对病情严重程度加以判断[3]。临床治疗AD采用糖皮质激素，长期使用糖皮质激素类药物药副反应明显，皮肤萎缩、色素沉淀、病情反复发作，临床效果欠佳[4]。现我院在原有治疗的基础上加用青鹏软膏，观察其对临床疗效的影响，分析如下。

1资料与方法

1.1一般资料 选取2016年1月～2017年1月在北京市普仁医院治疗的特应性皮炎患儿74例，本次研究经过医院伦理委员会批准。……