袁爱红

[摘要] 目的 分析观察口服降糖药物治疗妊娠糖尿病的效果。 方法 2015年1月—2017年10月时间，选择该院门诊收治的88例妊娠糖尿病患者，随机抽取其中的44例设为对照组，给予胰岛素治疗，余下44例设为治疗组，配合胰岛素与二甲双胍治疗，比较治疗前后的血糖水平，统计不良妊娠结局。结果 ①血糖水平分析，治疗前，组间FPG、2 hPG水平差异无统计学意义（P>0.05），但治疗后，治疗组FPG、2 hPG水平显著低于对照组，差异有统计学意义（P<0.05）。②统计不良妊娠结局，治疗组不良妊娠结局发生率为6.8%，对照组为15.9%，治疗组低于对照组，经比较，差异有统计学意义（P<0.05）。结论 妊娠糖尿病，配合口服降糖药治疗，疗效满意，不仅可控制血糖水平，而且可减少不良妊娠结局。

[关键词] 降糖药；妊娠糖尿病；临床效果

[中图分类号] R714.2 [文献标识码] A [文章编号] 1672-4062（2018）02（a）-0001-02

Research on Effect of Oral Administration of Hypoglycemic Drugs in Treatment of Gestational Diabetes

YUAN Ai-hong

Department of Internal Medicine， Hekou District Xinhu Health Center， Dongying， Shandong Province， 257236 China

[Abstract] Objective To analyze and observe the effect of oral administration of Hypoglycemic drugs in treatment of gestational diabetes. Methods 88 cases of patients with gestational diabetes admitted and treated in our hospital from January 2015 to October 2017 were selected and divided into two groups with 44 cases in each， the control group were treated with insulin， while the treatment group were treated with insulin combined with melbine， and the blood glucose levels before and after treatment were compared， and the adverse gestational outcomes were counted. Results ①The blood glucose level showed that the differences in the FPG and 2 hPG levels between the two groups before treatment were not obvious， without statistical significance（P>0.05）， after treatment， the FPG and 2 hPG levels in the treatment group were obviously lower than those in the control group， and the differences were statistically significant（P<0.05）.②the incidence rate of adverse gestational outcome in the treatment group and in the control group was respectively 6.8% and 15.9%， and the difference was statistically significant（P<0.05）. Conclusion The curative effect of oral administration of hypoglycemic drugs in treatment of gestational diabetes is satisfactory， which can not only control the blood glucose level but also reduce the adverse gestational outcomes.

[Key words] Hypoglycemic agent； Gestational outcome； Clinical effect

妊娠糖尿病，是妊娠期常见并发症，不仅会影响孕妇身心健康，而且不利于胎儿健康发育[1]。因此，早期对症治疗妊娠糖尿病，对母婴安全具有重要意义。在此，该院以2015年1月—2017年10月收治的88例门诊患者为对象，经实践探讨，观察分析口服降糖药物治疗妊娠糖尿病的临床疗效，现报道如下。

1 资料与方法

1.1 一般资料

选择该院门诊收治的88例妊娠糖尿病患者，随机抽取44例，设为对照组，余下44例设为治疗组。纳入标准：①符合妊娠糖尿病诊断标准。②经饮食与运动干预，血糖控制效果不佳者。③未出现糖尿病并发症，如视网膜病变、周围神经病变。④年龄20～40岁。⑤对该次研究知情，签署有知情同意书。⑥该次研究经医学伦理委员会审核批准。排除标准：①自身免疫性疾病。②心、肝、肾功能不良患者。③伴有糖尿病并发症者。④不愿参与研究的患者。⑤年龄>40岁，或者年龄<20岁的患者。对照组，23～38岁，平均（29.1±2.39）岁，孕周30～39周，平均（37.4±0.16）周，其中，31例初產妇，13例经产妇。治……