血清PG检测在胃癌早期筛查及术后监测中的应用
2018-06-13吴丽春陈茂顺
吴丽春 陈茂顺
【摘要】 目的:探讨血清PG检测在胃癌早期筛查及术后监测中的应用价值。方法:选取笔者所在医院2016年5月-2017年5月收治的胃癌患者86例,行全胃切除术者29例,为胃癌全胃切除术组,同时选取同期于笔者所在医院进行体检的健康人82例作为对照组,以胶乳免疫比浊法对所有患者血清PG含量进行检测,并对比檢测结果。结果:胃癌患者血清PGⅠ含量和PGⅠ/PGⅡ比值远低于健康对照组,差异均有统计学意义(P<0.05);胃癌全胃切除术组患者血清PGⅠ、PGⅡ含量远低于胃癌组患者,差异有统计学意义(P<0.05);术后复发组患者血清PGⅠ、PGⅡ含量远高于术后未复发组患者,差异有统计学意义(P<0.05)。结论:血清PG检测对胃癌早期筛查具一定指导作用,同时也可对胃癌术后复发情况进行监测,具较高应用价值。
【关键词】 血清PG检测; 胃癌; 术后监测
doi:10.14033/j.cnki.cfmr.2018.4.026 文献标识码 B 文章编号 1674-6805(2018)04-0053-02
Serum PG Detection was Used in Early Screening and Postoperative Monitoring of Gastric Cancer/WU Lichun,CHEN Maoshun.//Chinese and Foreign Medical Research,2018,16(4):53-54
【Abstract 】 Objective:To explore the value of serum PG detection in early screening and postoperative monitoring of gastric cancer.Method:86 cases of gastric cancer treated by our hospital from May 2016 to May 2017 were selected,at the same time, the healthy people who had the same time in our hospital were selected as the control group,the serum PG content of all patients was detected with the latex immunity and turbidity method, and the results were compared.Result:Gastric cancer patients with total gastrectomy group serum PG Ⅰ, PG Ⅱ content is far lower than the patients with gastric cancer group, Statistical significance (P<0.05);The difference between statistical significance (P<0.05); Postoperative recurrence patients serum PG Ⅰ, PG Ⅱ content is much higher than the group of patients, no postoperative recurrence statistical significance difference (P<0.05).Conclusion:The serum PG test can guide the early screening of gastric cancer, and it can also be used to monitor the recurrence of gastric cancer.
【Key words】 Serum PG detection; Gastric cancer; Postoperative monitoring
First-authors address:The Third Hospital in Zhangzhou City, Zhangzhou 363000,China
临床检测胃癌通常采取胃镜检查或是上消化道造影[1]。近些年来,相关研究发现,血清蛋白酶原(PG)检测对胃癌早期具一定诊断作用[2]。为探讨血清PG检测在胃癌早期筛查及术后监测中的应用价值,本案选取了86例胃癌患者为对象进行研究,现报道如下。
1 资料与方法
1.1 一般资料
选取86例笔者所在医院于2016年5月-2017年5月收治的胃癌患者为胃癌组,所有患者均经胃镜及病理学活检检查确诊,其中男58例,女28例;年龄28~76岁,平均(54.4±5.6)岁;行全胃切除术者29例,为胃癌全胃切除术组,其中男20例,女
9例;年龄29~76岁,平均(54.5±5.3)岁;经随访术后未复发者20例,为术后无复发组;术后复发者9例,为术后复发组。另选82例同期于笔者所在医院进行体检的健康人作为对照组,其中男47例,女35例;年龄25~78岁,平均(53.2±6.3)岁。各组患者一般资料比较差异无统计学意义(P>0.05),具有可比性。
1.2 方法
所有研究对象均于清晨抽取3 ml空腹静脉血,行血清分离后置于-20℃冰箱保存待检。利用胶乳免疫比浊法进行检测,试剂盒为胃蛋白酶原I测定试剂盒(北京九强生物技术有限公司),仪器:OLYMPUS5421全自动生化分析仪。……
