孙庆　夏兆芳

【摘要】 目的：探讨健脾益肾解毒法（扶正解毒冲剂）对肾癌（Ⅱ期）术后肿瘤指标及免疫功能影响。方法：自2014年1月-2017年1月随访肾透明细胞癌（Ⅱ期）根治术后患者，中医辨证为脾肾亏虚，毒邪留恋型160例，分成两组，每组80例，对照组注射胸腺五肽20 mg/次，2次/周，治疗组口服扶正解毒冲剂，治疗6个月，分别在第3、6个月抽取静脉血，检测肿瘤细胞标记物的变化，细胞因子的变化，做统计学处理。结果：治疗3、6个月后治疗组肿瘤坏死因子、肾抑癌基因、白介素-2、白介素-3均高于对照组，差异均有统计学意义（P<0.01）。结论：应用健脾益肾解毒法（扶正解毒冲剂）治疗肾癌术后患者能够提高肿瘤抑制因子含量，提高免疫力，从而抑制肾癌复发。

【关键词】 健脾益肾解毒法； 肾癌； 细胞因子

doi：10.14033/j.cnki.cfmr.2018.4.002 文献标识码 A 文章编号 1674-6805（2018）04-0003-03

Effects of the Centralizer Jiedu Granule on Ⅱ period Postoperative Cytokine Kidney Cancer/SUN Qing，XIA Zhaofang.//Chinese and Foreign Medical Research，2018，16（4）：3-5

【Abstract】 Objective：To discuss the effects of the Centralizer Jiedu Granule on Ⅱ period postoperative cytokine kidney cancer.Method：Patients enrolled were from patients with postoperative renal clear cell carcinoma who were followed up for 3 years from January 2014 to January 2017.All the 160 cases with diagnosis of traditional Chinese medicine for asthenia of both spleen and kidney together with the toxin factor，including 100 males and 60 females，were randomly divided into two groups， each group of 80 patients.The placebo group received oral compound vitamin B for 6 months，and the treatment group was treated by oral fuzheng detoxification infusion.Venous and iliac bone blood were collected at the third month and the sixth month respectively to detect the expression changes of PDGF（platelet-derived growth factor），VEGF（vascular endothelial growth factor）-A，VHL （renal tumor suppressor genes），tumor necrosis factor （TNF-α）， interleukin 2 and interleukin 3.All the data were statistically processed.Result：The tumor necrosis factor， renal tumor suppressor gene， interleukin-2 and interleukin-3 were all higher than the control group in the treatment group after 3 and 6 months，and the differences were statistically significant （P<0.01）.Conclusion：The treatment of patients with kidney cancer after treatment of kidney cancer can improve the content of tumor suppressive factor and improve immunity， thereby inhibiting the recurrence of renal carcinoma.

【Key words】 Spleen and kidney detoxification method； Kidney cancer； Cytokines

First-authors address：Jinan Traditional Chinese Medicine Hospital，Jinan 250012，China

肾癌（carcinoma of kidney）又称肾细胞癌，肾腺癌，起源于肾小管上皮细胞，属于上皮源性的恶性肿瘤，可发生于肾实质的任何部位，但以上、下极为多见，少数侵及全肾；左、右肾发病机会均等，双侧病变占1%～2%。手术切除是腎癌的主要治疗方法，可治愈大部分的早期患者，但手术后的复发率仍高达20%～40%[1]，肾癌容易发生转移的部位是淋巴结、肺、骨、脑等器官。转移性肾癌的预后相当差，中位生存期6～12个月， 5年生存率小于10%。肾癌的化疗效果不理想，转移性肾癌对患者的生活和工作质量造成了极大的危害，影响人们生活和工作。因此转移性肾癌的治疗仍是临床上面临的一项重大挑战，本课题通过试验探索扶正解毒冲剂对肾细胞癌的作用，观察中药能否延迟肾细胞癌的休眠期，延长患者的生命。同时通过试验，为中药治疗肾细胞癌提供依据。……