高玉琳

[摘要] 目的 研究慢性湿疹采用氯雷他定联合大椎穴敷贴治疗的效果。 方法 将144例慢性湿疹患者分成对照组和治疗组，每组72例。对照组单纯采用氯雷他定进行治疗；治疗组采用氯雷他定联合大椎穴敷贴进行治疗，比较两组治疗效果及不良反应发生率，记录患者治疗前后各实验室指标变化、症状消失时间及治疗总时间。 结果 治疗组患者慢性湿疹治疗总有效率为90.3%明显高于对照组的73.6%（P<0.05）；用药过程中出现的不良反应仅有3例，少于对照组的12例（P<0.05）；在用药治疗前后胸腺活化调节趋化因子、免疫球蛋白、嗜酸性粒细胞计数相关指标水平上，治疗组的改善幅度大于对照组（P<0.05）；湿疹症状消失时间和治疗总时间短于对照组（P<0.05）。 结论 慢性湿疹患者采用氯雷他定联合大椎穴敷贴进行治疗，能够在短时间内控制症状，减少不良反应，提高治疗效果。

[关键词] 慢性；湿疹；氯雷他定；大椎穴敷贴

[中图分类号] R758.23 [文献标识码] B [文章编号] 1673-9701（2018）02-0086-03

[Abstract] Objective To study the therapeutic effect of loratadine combined with Dazhui acupoint external application on chronic eczema. Methods 144 patients with chronic eczema were divided into control group and treatment group， with 72 cases in each group. The control group was treated with loratadine alone， and the treatment group was treated with loratadine combined with traditional Chinese medicine Dazhui acupoint external application. The treatment effect and the incidence of adverse reactions were compared between the two groups. The changes of laboratory indexes， disappearance time of symptoms and total treatment time were recorded. Results The total effective rate of chronic eczema （90.3%） in treatment group was obviously higher than 73.6% in control group（P<0.05）. There were only 3 cases of adverse reactions in treatment group， fewer than 12 cases in control group（P<0.05）. The disappearance time and the total time of treatment for eczema were shorter than those in the control group（P<0.05）. The impovement of thymic activation-regulated chemokine， immunoglobulin and eosinophil count before and after treatment was greater than that of the control group（P<0.05）. Conclusion Loratadine combined with traditional Chinese medicine Dazhui acupoint external application used in chronic eczema patients can control the symptoms in a short time， reduce adverse reactions and improve the therapeutic effect.

[Key words] Chronic； Eczema； Loratadine； Dazhui acupoint external application

慢性濕疹近年来已经成为临床皮肤科中较为常见的一种多发疾病，在中医学理论中该病属于“湿疮”的范畴[1，2]。慢性湿疹病情迁延反复，发病机制相对复杂，目前还不是完全清楚，近年来普遍认为是由于内外激发性因素共同作用后，出现的迟发型变态反应的一种类型。中医学对湿疹治疗的历史较为悠久，且所能应用的方法相对较多，已经不仅仅局限于单纯口服或外洗用药两种途径。如何能够使中医学在该疾病治疗的优势得到更加充分的发挥，使患者的病情能够在短时间内得到控制，防止病情在治疗后反复出现，已经成为近年来临床及相关领域所研究的一个重点。本文研究慢性湿疹患者采用氯雷他定联合大椎穴敷贴进行治疗的临床效果，现报道如下。

1 资料与方法

1.1 一般资料

选取于2015年9月～2017年9月在我院接受治疗的144例慢性湿疹患者，将其随机分成对照组和治疗组，每组各72例。……