陈国松+周桂华+朱双华

[摘要] 目的 探讨分析异甘草酸镁对巨细胞病毒性肝炎患儿肝功能生化指标的影响。方法 方便选取该院2010年3月—2016年3月收治的122例巨细胞病毒性肝炎患儿作为实验对象，随机分成实验组与对照组，各61例，对照组使用更昔洛韦治疗，实验组使用异甘草酸镁治疗，比较分析两组患儿肝功能生化指标改善情况。 结果 实验组患儿的ALT（谷丙转氨酶）、AST（谷草转氨酶）及TBIL（总胆红素）等肝功能生化指标水平分别为（46.07±4.42）U/L、（51.08±7.28）U/L、（49.26±8.81）μmol/L，明显低于对照组（81.05±6.73）U/L、（88.34±3.92）U/L、（117.61±11.85）μmol/L（P<0.05）；对照组患儿治疗总有效率为59.02%，实验组为86.89%，实验组治疗总有效率明显高于对照组，两组比较差异有统计学意义；实验组患儿不良反应发生率为4.92%（3/61），对照组为8.19%（5/61），两组患儿不良反应发生几率差异无统计学意义（P>0.05）。结论 异甘草酸镁对巨细胞病毒性肝炎患儿肝功能生化指标的影响较好，能显著改善患儿肝功能生化指标，提高其治疗总有效率，值得使用与推广。

[关键词] 异甘草酸镁；巨细胞病毒性肝炎；肝功能；生化指标

[中图分类号] R725 [文献标识码] A [文章编号] 1674-0742（2017）12（b）-0048-03

[Abstract] Objective To study and analyze the effect of magnesium isoglycyrrhizinate on the liver function biochemical indicators of children with cytomegalovirus hepatitis. Methods 122 cases of children with cytomegalovirus hepatitis admitted and treated in our hospital from March 2010 to March 2016 convenient were selected and randomly divided into two groups with 61 cases in each， the control group were treated with ganciclovir， while the experimental group were treated with magnesium isoglycyrrhizinate， and the improvement of liver function biochemical indicators were compared between the two groups. Results The levels of live function biochemical indicators such as ALT， AST and TBIL in the experimental group were obviously lower than those in the control group[（46.07±4.42）U/L，（51.08±7.28）U/L，（49.26±8.81）μmol/L vs （81.05±6.73）U/L， （88.34±3.92）U/L， （117.61±11.85）μmol/L]（P<0.05）， and the total effective rate in the experimental group was obviously higher than that in the control group（59.02% vs 86.89%）， and the difference was statistically significant， and the incidence rate of adverse reactions in the experimental group and in the control group was respectively 4.92%（3/61） and 8.19%（5/61）， and the difference between groups was not statistically significant（P>0.05）. Conclusion The effect of magnesium isoglycyrrhizinate on the liver function biochemical indicators of children with cytomegalovirus hepatitis is better， which can obviously improve the liver function biochemical indicators and improve the total treatment effective rate， and it is worth application and promotion.

[Key words] Magnesium isoglycyrrhizinate； Cytomegalovirus hepatitis； Liver function； Biochemical indicators

巨細胞病毒性肝炎发病原因主要是新生儿先天性或围生期出现巨细胞病毒感染，临床表现主要是黄疸、肝功能损害等，部分患儿则会发生生长发育迟缓及心脏畸形等等，严重影响新生儿的健康生长。更替洛韦是临床上治疗巨细胞病毒性肝炎的主要药物，能抑制病毒复制，但是在胆汁排泄异常及肝纤维化方面疗效不理想。异甘草酸镁是一种肝细胞保护剂，具有良好的解毒、抗炎及保护肝细胞膜作用，在肝病治疗中应用较广泛，但是其应用于巨细胞病毒性肝炎治疗研究较少[1]。该次实验研究通过对该院2010年3月—2016年3月收治的122例巨细胞病毒性肝炎患儿进行观察，分析异甘草酸镁对巨细胞病毒性肝炎患儿肝功能生化指标的影响，现报道如下。……