阙金亚

[摘要] 目的 探究联合检测CA125、CA199和CEA对于卵巢癌诊断的临床意义。方法 随机选取该院在2015年1月—2018年1月期间接受治疗的卵巢癌患者30例作为研究组，卵巢癌良性疾病患者30例作为对照A组，同时前来体检的健康人群30例作为对照B组，对比3组人员的CA125、CA199和CEA水平并进行相应的分析。结果 对照A组良性病变患者CA125为（32.7±8.2）U/mL，CA199为（33.5±8.5）U/mL，CEA为（10.7±4.5）U/mL，与健康人群相比差异无统计学意义（P>0.05）；治疗组患者CA125为（312.7±22.8）U/mL，CA199为（133.4±15.1）U/mL，CEA为（27.3±8.5）U/mL，均显著高于正常健康人群的水平（P<0.05）；对照A组良性病变患者的CA125检出率为13.33%，CA199阳性检出率为16.67%，CEA阳性检出率为6.67%，联合检出率为23.33%，与健康人群相比差异无统计学意义（P>0.05）；治疗组CA125检出率为73.33%，CA199阳性检出率为53.33%，CEA阳性检出率为33.33%，联合检出率为93.33%，均显著高于健康人群（P<0.05）。结论 联合检测CA125、CA199和CEA水平有利于卵巢癌的检出，这对于临床上诊断出卵巢癌具有显著意义，值得参考。

[关键词] CA125；CA199；CEA；联合诊断；卵巢癌

[中图分类号] R737 [文献标识码] A [文章编号] 1674-0742（2018）09（b）-0183-03

[Abstract] Objective To investigate the clinical significance of combined detection of CA125， CA199 and CEA in the diagnosis of ovarian cancer. Methods 30 patients with ovarian cancer who were convenient treated in the hospital from January to February 2018 were enrolled in the study group. 30 patients with benign ovarian cancer were included in the control group A， and 30 healthy people from the physical examination were used as control group B， the CA125， CA199 and CEA levels of the three groups were compared and analyzed accordingly. Results Compared with group A， patients with benign lesions had CA125 of（32.7±8.2）U/mL， CA199 of （33.5±8.5）U/mL， and CEA of （10.7±4.5）U/mL. There was no significant difference compared with healthy people （P>0.05）； CA125 was （312.7±22.8）U/mL， CA199 was （133.4±15.1）U/mL， and CEA was （27.3±8.5） U/mL， which was significantly higher than that of normal healthy people. The level of CA125 in patients with benign lesions of control group A was 13.33%， the positive rate of CA199 was 16.67%， the positive rate of CEA was 6.67%， and the combined detection rate was 23.33%. There was no significant difference in the population （P>0.05）. The detection rate of CA125 in the treatment group was 73.33%， the positive rate of CA199 was 53.33%， the positive rate of CEA was 33.33%， and the combined detection rate was 93.33%. They were significantly higher than healthy people （P<0.05）. Conclusion The combined detection of CA125， CA199 and CEA levels is conducive to the detection of ovarian cancer， which is of great significance for the clinical diagnosis of ovarian cancer， worthy of reference.

[Key words] CA125； CA199； CEA； Combined diagnosis； Ovarian cancer

卵巢癌為长在卵巢上的恶性肿瘤[1]，是女性生殖器官中常见的一种恶性肿瘤，其中卵巢上皮癌死亡率占首位[2]，对女性健康造成极大的威胁。该种肿瘤早期症状不明显[3]，因而一般在发现时已发展为晚期，且扩散到子宫，盆腔器官，双侧附件等[4]，为治疗带来极大的难度。近年来有研究发现进行CA199，CA125，CEA等指标的鉴定有利于卵巢癌的检出，该次研究随机选取该院在2015年1月—2018年1月期间接受治疗的卵巢癌患者与卵巢癌良性疾病患者30例进行研究，拟探究联合检测CA125、CA199和CEA对于卵巢癌诊断的临床意义，现报道如下。

1 资料与方法

1.1 一般资料

随机选择在接受治疗的卵巢癌患者30例作为研究组，卵巢癌良性疾病患者30例作为对照A组，同时前来体检的健康人群30名作为对照B组，其中对照B组年龄为32～78岁，平均年龄为（45.4±5.5）岁；对照A组年龄为33～78岁，平均年龄为（46.2±5.8）岁；治……