七氟醚与丙泊酚麻醉对2型糖尿病胃癌患者麻醉中血糖和胰岛素的影响
2018-01-03林绍立林梁洪甲庚王庆祥
林绍立 林梁 洪甲庚 王庆祥


[摘要] 目的 研究在2型糖尿病胃癌患者麻醉中应用七氟醚麻醉、丙泊酚麻醉的不同效果。方法 选择该院2016年1月—2017年12月收治的38例2型糖尿病胃癌患者进行研究,随机将38例患者分为两组,每组均有19例,分别接受七氟醚麻醉、丙泊酚麻醉,相应视作七氟醚组、丙泊酚组,比较两组血糖水平及胰岛素水平变化情况。 结果 丙泊酚组、七氟醚组麻醉诱导前5 min血糖水平比较差异无统计学意义(P>0.05),丙泊酚组诱导后5 min、麻醉后2 h血糖水平均低于七氟醚组(P<0.05);丙泊酚组、七氟醚组麻醉诱导前5 min胰岛素水平比较差异无统计学意义(P>0.05)),丙泊酚组诱导后5 min、麻醉后2 h胰岛素水平均高于七氟醚组(P<0.05)。结论 在2型糖尿病胃癌患者麻醉中,选择丙泊酚进行麻醉能够减小对患者血糖水平、胰岛素水平的影响,较七氟醚更值得推广。
[关键词] 2型糖尿病;胃癌;七氟醚;丙泊酚;麻醉;血糖;胰岛素
[中图分类号] R614 [文献标识码] A [文章编号] 1672-4062(2018)09(a)-0011-03
Effects of Sevoflurane and Propofol Anesthesia on Blood Glucose and Insulin in Patients with Type 2 Diabetes Mellitus
LIN Shao-li, LIN Liang, HONG Jia-geng, WANG Qing-xiang
Department of Anesthesiology, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian Province, 361003 China
[Abstract] Objective To study the different effects of sevoflurane anesthesia and propofol anesthesia in anesthesia of type 2 diabetic patients with gastric cancer. Methods A total of 38 patients with type 2 diabetes mellitus from January 2016 to December 2017 were selected and enrolled. A total of 38 patients were randomized into two groups, each with 19 patients receiving sevoflurane anesthesia, propofol anesthesia, respectively as the sevoflurane group, propofol group, compare the changes of blood glucose levels and insulin levels in the two groups. Results There was no significant difference in blood glucose levels between propofol group and sevoflurane group of 5 minutes before anesthesia induction (P>0.05). The blood glucose level was lower than that of sevoflurane group 5 minutes after propofol group induction and 2 hours after anesthesia (P<0.05); there was no significant difference in insulin levels between propofol group and sevoflurane group 5 minutes before induction of anesthesia(P>0.05), 5 minutes after propofol group induction, 2 hours after anesthesia, insulin level was higher than sevoflurane group (P<0.05). Conclusion In the anesthesia of type 2 diabetic patients with gastric cancer, the choice of propofol for anesthesia can reduce the impact on blood glucose levels and insulin levels, which is more worthy of promotion than sevoflurane.
[Key words] Type 2 diabetes; Gastric cancer; Sevoflurane; Propofol; Anesthesia; Blood glucose; Insulin
胃癌屬于消化道多发恶性肿瘤,近些年临床统计数据显示胃癌的发病率逐渐升高,并且发现一些患者同时存在2型糖尿病[1]。有研究显示,持续处于高血糖水平的患者患胃癌的可能性更大,高血糖、胃癌的发病上存在关联性,不过因为对糖尿病、胃癌的相关性还没有足够认识,所以还没有发现有效的治疗方案,使得患者可能无法接受及时、有效的治疗,导致生存质量受到明显影响[2]。从当前实践情况来看,手术依旧是治疗2型糖尿病胃癌的重要方法,但是因为手术麻醉存在刺激性、伤害性,可能导致内分泌系统、免疫系统出现功能方面的紊乱,严重损伤患者的组织功能[3],所以选择合适的麻醉方式具有重要意义。该研究具体比较七氟醚与丙泊酚麻醉用于2型糖尿病胃癌中的不同效果,选取该院2016年1月—2017年12月收治的38例患者进行研究,现报道如下。……p>
