龙平++洛若愚

[摘要] 目的 探讨腹腔镜联合醋酸亮丙瑞林治疗子宫内膜异位症合并不孕的临床效果。 方法 选取2014年7月～2016年1月武漢大学人民医院收治的105例子宫内膜异位症合并不孕患者，根据患者治疗方案不同分为对照组（50例）与观察组（55例）。对照组实施腹腔镜手术治疗，观察组在腹腔镜手术基础上联合药物治疗。比较两组患者临床疗效、术后并发症发生率、血清CA125水平及1年内妊娠率。 结果 观察组患者临床总有效率为96.36%，高于对照组（80.00%），差异有统计学意义（P < 0.05）。两组患者治疗前血清CA125水平差异无统计学意义（P > 0.05）；治疗后两组患者血清CA125水平与治疗前相比均下降，差异有统计学意义（P < 0.05）；治疗后两组患者血清CA125水平比较，差异无统计学意义（P > 0.05）。观察组并发症发生率（1.82%）低于对照组（8.00%），但差异无统计学意义（P > 0.05）。观察组患者1年内妊娠率（56.36%）高于对照组（14.00%），差异有统计学意义（P < 0.05）。 结论 腹腔镜与药物醋酸亮丙瑞林联合治疗子宫内膜异位症合并不孕患者的效果较好，并发症少且妊娠率高，具有一定临床推广应用价值。

[关键词] 子宫内膜异位症；不孕；腹腔镜；妊娠率

[中图分类号] R711.71 [文献标识码] A [文章编号] 1673-7210（2017）09（b）-0076-04

Clinical effect of laparoscopy combined with Leuprolide Acetate in the treatment of endometriosis complicated with infertility

LONG Ping LUO Ruoyu

The First Department of Gynecology， Renmin Hospital of Wuhan University， Hubei Province， Wuhan 430060， China

[Abstract] Objective To investigate the clinical effect of laparoscopy combined with Leuprolide Acetate in the treatment of endometriosis complicated with infertility. Methods 105 cases of patients with endometriosis complicated with infertility treated in Renmin Hospital of Wuhan University from July 2014 to January 2016 were selected. According to the different treatment methods， patients were divided into the control group （50 cases） and the observation group （55 cases）. Patients of the control group were given laparoscopic surgery treatment， patients of the observation group were given drug therapy on the basis of the laparoscopic surgery. The clinical efficacy， postoperative complication rate， serum CA125 level and the rate of pregnancy in 1 year were compared between the two groups. Results The total clinical efficacy rate of the observation group was 96.36%， which was higher than 80.00% of the control group， with statistically significant difference （P < 0.05）. There were no statistically significant differences in serum CA125 levels before and after treatment between the two groups （P > 0.05）， however， after treatment the serum CA125 levels of the two groups were decreased than before treatment （P < 0.05）. The complication rate of the observation group was 1.82%， which was lower than 8.00% of the control group， but the difference was not statistically significant （P > 0.05）. The pregnancy rate in 1 year of the observation group was 56.36%， which was higher than 14.00% of the control group， with statistically significant difference （P < 0.05）. Conclusion Laparoscopy combined with Leuprolide Acetate in the treatment of endometriosis complicated with infertility has better efficacy， lower complications and higher pregnancy rate. It is worthy of clinical application.endprint

[Key words] Endometriosis； Infertility； Laparoscope； Pregnancy rate

子宫内膜异位症为妇科常见疾病类型，其中合并不孕的概率较高，对患者日常生活、家庭幸福以及生命健康等均造成一定影响[1]。寻找恰当治疗方案对子宫内膜异位症合并不孕患者十分重要，目前临床多采用腹腔镜手术治疗效果较好。但有研究指出，单纯采用腹腔镜手术治疗效果不佳，配合药物治疗效果更好[2]。本研究观察子宫内膜异位症合并不孕患者应用腹腔镜与药物联合治疗方案的效果，报道如下：

1 资料与方法

1.1 一般资料

选取2014年7月～2016年1月于武汉大学人民医院接受治疗的子宫内膜异位症合并不孕患者105例作为研究对象，根据患者治疗方案不同分组，其中，对照组50例，观察组55例。对……