综合干预治疗对重型-地中海贫血青春期女性生长发育的效果观察
2017-10-09魏苗苗黄晓东高志娟陈国华
郑 虹 丁 凤 魏苗苗 张 旸 黄晓东 高志娟 陈国华
广东省惠州市第一人民医院(516000)
·临床分析·
郑 虹 丁 凤 魏苗苗 张 旸 黄晓东 高志娟 陈国华
广东省惠州市第一人民医院(516000)
1 材料与方法
1.1一般资料
1.2数据获取及干预方法
1.3仪器与试剂
LH、FSH、E2测定采用美国 Abbott 公司的 I-2000 发光免疫分析仪及配套试剂,严格按照说明书进行操作。超声诊断采用美国 Voluson E8彩超仪、日本东芝NemioMX超声诊断仪。
1.4统计学分析
2 结果
2.1各组对象治疗前后临床指证测定比较
表1 各组研究对象治疗前后临床指证比较
*与对照组比较P<0.05
2.2各组对象治疗前后血中性激素比较
2.3各组对象治疗前后性腺发育变化比较
表2 各组研究对象治疗前后血清生殖激素水平比较
*与对照组比较P<0.05
表3 各组研究对象治疗前后性腺发育情况比较
*与对照组比较P<0.05
3 讨论
3.1重型地贫的相关研究状况
3.2目前重型地贫的治疗方法
3.3本研究结果发现
[1] Muncie HL Jr,Campbell J.Alpha and beta thalassemia[J].Am FamPhysician, 2009, 80(4):339-344.
[2] De Sanctis V, A.Eleftheriou, C.Malaventura.Prevalence of endocrine complications and short stature in patients with thalassaemia major: a multicenter study by the Thalassaemia International Federation (TIF) [J].Pediatr Endocrinol Rev, 2004, 2 Suppl 2:249-255.
[3] Moayeri H., Z.Oloomi.Prevalence of growth and puberty failure with respect to growth hormone and gonadotropins secretion in beta-thalassemia major [J].Arch Iran Med, 2006, 9(4):329-334.
[4] 陆时运, 周仲昊, 王晨, 等.去铁胺治疗长期输血所致铁过载的疗效观察[J].隋床医药实践, 2011, 20 (2):110-112.
[5] Belhoul,Bakir ML,et al.Prevalence of iron overload complications among patients with b-thalassemia major treated at Dubai Thalassemia Centre[J].Ann Saudi Med.2013, 33(1):18-21.
[6] Yin XL,Wu ZK, He YY,et al.Treatment and complications of thalassemia major in Gangxi,Southern China[J].Pediatr Blood Cancer 2011,57(7):1174-1178.
[8] 王燕燕, 李晓辉, 徐西华.地中海贫血诊治进展与我国现状[J].中国实用儿科杂志,2013, 28 (6) : 473-476.
[9] Al-Rimawi HS,Jallad MF,Amarin ZO,et al.Hypoth alamic-pituitarygonadal function in adolescent females with beta-thalassemia major [J].Int JGyneco bstet,2005, 1(90):44-47.
[10] Karamifarh, Shahriarim, Et A.L Amirhakimigh.Failure of puberty and linear growth in beta- thalassemia major[J].Turk Haematol, 2005, 22(2):65-69.
[11] Borgna-Pignatri C, Rugoloeto S, De StefanoP, et al.Survival and complications in patients with beta-thalassaemia major treated with transfusin and deferoxamine.Haematologila, 2004,89(10):1187-1193.
[12] 张新华, 黄有文.血液病诊断及疗效标准//张之南,沈梯,主编.血液病诊断与疗效标准.3版.北京:科学技术出版社,2007:29-34.
[13] De Sanctis V.Growth and puberty and its management in thalassaemiac[J].Horm Res,2007,58(Suppl 1):72-79.
[14] Heshmat Moayeri,Zohreh Oloomi.Prevalence of Growth and Puberty Failure with Respect to Growth Hormone and Gonadotropins Secretion in Beta-Thalassemia Major[J].Arch Iran Med,2006,9(4):331-333.
[15] C Roth A, Pekrun M, Bartz H, et al.Short stature and failure of pubertal development in thalassasemia major: evidence for hypothalamic neurosecretory dysfunction of growth hormone secretion and defective pituitary gonadotropin secretion[J].Eur J Pediatr,1997,156:778-781.
[16] 李辉, 季成, 叶宗南, 等.2009年中国0-18岁儿童身高、体重的标准化生长曲线.中华儿科杂志[J] .2009, 47 (7):487-492.
[17] Pan HF, Long GF, Li Q, et al.Current status ofthalassemia in minority populations in Gangxi, China[J].Clin Genet,2007,71 (5):419-426.
[20] Shander A, Sazam a K.C finical consequences of iron overload from chronic red blood cell transfusions,its diagnosis,and its management by chelation therapy.Transfusion, 2010, 50(5): 1144-1155.
[21] Taksande A,Prabhu S,Venkatesh S.Cardiovascular aspect of Beta thalassemia.Cardiovasc Hematol Agents Med Chem[J].2012 Mar 1;10(1):25-30.
[22] Thalassemia.International Federation:Guidelines for the clinical management of thalassemia 2nd edition.2010.
[24] 吴学东, 井远方, 温建芸, 等.造血干细胞移植治疗地中海贫血[J].中国组织工程研究,2012, 6 (23):4339 -4348.
[25] Angelucci E .Hematopoietic stem cell transplantation in thalassemia[J] .Hematology Am Soc Hematol Educ Program, 2010, 456 -462.
[26] Schrier SL, Angehicei E .New strategies in the treatment of the thalassemias [J].Annu Rev Med, 2005,56: 157-171.
[责任编辑:董 琳]
ZHENG Hong, DING Feng, WEI Miaomiao, ZHANG Yang, HUANG Xiaodong, GAO Zhijuan, CHEN Guohua
TheFirstpeople’sHospitalofHuizhou,Guangdong, 516000
10.3969/j.issn.1004-8189.2017.06.007
广东省惠州市科技计划项目(2014Y042)
2017-01-00
2017-03-15