黄欢

[摘要] 目的 探讨狼疮性肾炎患者血清白介素-6、白介素-10水平及临床意义。 方法 选择2014年1月～2016年6月在我院诊断为狼疮性肾炎患者40例为实验组，其中20例患者处于活动期，缓解期患者20例，另选择同期健康体检志愿者20例为对照组。检测三组血清IL-6及IL-10水平。 结果 实验组活动期IL-6及IL-10水平显著高于缓解期及对照组，差异有统计学意义（P<0.05）。缓解期IL-6及IL-10水平显著高于对照组，差异有统计学意义（P<0.05）。实验组活动期Trge水平显著低于缓解期以及对照组，差异有统计学意义（P<0.05）；实验组活动期CD19+CD69+显著高于缓解期以及对照组，缓解期显著高于对照组，差异有统计学意义（P<0.05）。 结论 狼疮性肾炎活动期患者血清IL-6、IL-10以及B淋巴细胞水平显著升高，Treg水平下降，其可以作为临床判断狼疮性肾炎活动程度的相关指标。

[关键词] 白介素-6；白介素-10；狼疮性肾炎

[中图分类号] R593.242 [文献标识码] A [文章编号] 2095-0616（2017）13-248-04

[Abstract] Objective To explore levels and clinical significance of serum interleukin-6 and interleukin-10 of patients with lupus nephritis. Methods 40 patients who were diagnosed as lupus nephritis in our hospital from January 2014 to June 2016 were selected as the experimental group.Among whom，20 patients were in active stage and 20 patients were in remission stage.20 healthy volunteers during the same period were selected as the control group.Serum interleukin-6 and interleukin-10 levels of three groups were detected. Results Serum interleukin-6 and interleukin-10 levels in active stage of the experimental group were higher than those in remission stage and those of the control group.The difference was statistically significant（P<0.05）.Serum interleukin-6 and interleukin-10 levels in remission stage were significantly higher than those of the control group.The difference was statistically significant（P<0.05）.Trge level in active stage of the experimental group was significantly lower than that of the remission stage and the control group.The difference was statistically significant（P<0.05）.CD19+CD69+ in active stage of the experimental group was significantly higher than that of the remission stage and that of the control group.And the remission was significantly higher than the control group.The difference was statistically significant（P<0.05）. Conclusion Levels of serum IL-6，IL-10 and B lymphocyte of patients with lupus nephritis are significantly increased while Treg was decreased.They can be regarded as related index to judge the activity of lupus nephritis in clinic.

[Key words] Interleukin-6；Interleukin-10；Lupus nephritis

系统性红斑狼疮（SLE）是一种多发于青年女性的累及多臟器的自身免疫性炎症性结缔组织病，早期、轻型和不典型的病例日渐增多。本病病因至今尚未肯定，大量研究显示遗传、内分泌、感染、免疫异常和一些环境因素与本病的发病有关。狼疮性肾炎的发病机制还不十分清楚，涉及多种因素，目前学界认为狼疮性肾炎由免疫复合物介导，B细胞功能亢进，T细胞功能异常，自身免疫耐受丧失。细胞因子在狼疮性肾炎的发生及发展过程中也发挥了重要的作用[1-2]。本研究分析IL-6及IL-10对狼疮性肾炎的影响。现将结果报道如下。

1 资料与方法

1.1 一般资料

选择2014年1月～2016年6月在我院诊断为狼疮性肾炎患者40例为实验组。纳入标准：狼疮肾炎诊断明确，血肌酐低于176.8μmol/L。排除标准：合并其他自身免疫性疾病者，合并严重感染者，合并其他系统实质性病变的患者，肌酐>176.8μmol/L。其中20例患者处于活动期，男4例，女16例，年龄16～60岁；病理分型：Ⅱ型1例，Ⅲ型4例，Ⅳ型13例，Ⅴ型2例。缓解期患者20例，男5例，女15例，年龄15～58岁；病理分型：Ⅱ型2例，Ⅲ型3例，Ⅳ型13例，Ⅴ型2例。……