余和晏

摘要：目的 研究并分析治疗十二指肠溃疡出血患者时使用泮托拉唑联合生长抑素的效果。方法 收集十二指肠溃疡出血患者共114例，根据随机分配方案将其分为对照组（57例）和观察组（57例），对照组的治疗药物为泮托拉唑，观察组则联合使用生长抑素，将两组临床疗效及再出血发生率进行观察和对比。结果 观察组的总有效率为94.74%，显著高于对照组的75.44%，χ2=8.365，P=0.004；观察组的再出血发生率为3.51%，显著低于对照组的28.07%，P=0.000。结论 在十二指肠溃疡出血患者的治疗过程中，泮托拉唑联合生长抑素能够使患者获得更佳疗效，并显著降低再出血的发生风险，值得推广应用。

关键词：十二指肠溃疡；出血；泮托拉唑；生长抑素；联合治疗；再出血发生率

中图分类号：R573.1 文献标识码：A 文章编号：1006-1959（2017）13-0003-02

Abstract：Objective To study the effect of the treatment of duodenal ulcer and bleeding patients using pantoprazole combined with somatostatin. Methods A total of 114 cases of patients with duodenal ulcer bleeding，according to the random allocation scheme will be divided into control group （57 cases）and observation group（57 cases），the control group was treated with pantoprazole，and the observation group was treated with somatostatin.The clinical efficacy and the rate of rebleeding were observed and compared.Results The total effective rate was 94.74% in the observation group，which was significantly higher than that in the control group，75.44%，χ2=8.365，P=0.004.The incidence of rebleeding in the observation group was 3.51%， which was significantly lower than that in the control group，28.07%，P=0.000.Conclusion Pantoprazole combined with somatostatin can improve the curative effect of patients with duodenal ulcer bleeding and significantly reduce the risk of rebleeding，which is worthy of popularization and application.

Key words：Duodenal ulcer；Bleeding；Pantoprazole；Somatostatin；Combined therapy；Rebleeding rate

十二指肠溃疡属于消化性溃疡的常见病，在冬春两季好发，且男性的发病率高于女性[1]。相关的研究报道称，十二指肠溃疡的发病与幽门螺杆菌感染、胃酸分泌异常、生活饮食不规律、非甾体抗炎药、吸烟饮酒、工作压力、精神心理因素等均有着密切的关系[2]。患者在发病时其上腹部会出现疼痛感，表现为剧痛、胀痛、灼痛或钝痛，该疼痛会呈现节律性，且能够持续几周甚至数月。一旦合并出血出现，则具有一定程度的高危性，且患者的病死率较高，因此及时有效的止血治疗对于患者预后有着关键意义[3]。在本次研究中，对十二指肠溃疡出血患者采用了泮托拉唑联合生长抑素的治疗方案，现……