【摘要】 目的：探討女性性激素、血脂水平对女性膀胱出口梗阻的影响。方法：收集笔者所在医院2015年1月-2016年12月就诊的围绝经期及绝经后诊断为女性膀胱出口梗阻患者30例，根据Blaivas-Groutz计算图，对女性膀胱出口梗阻进行分度，将其分为轻度梗阻（16例）和中、重度梗阻（14例），对其采血检测性激素，及血脂。对同期非女性膀胱出口梗阻40例患者采血检测性激素。结果：FBOO组和非FBOO组FSH、LH、E2水平比较，差异有统计学意义（P<0.05），FBOO组FSH、LH显著高于非FBOO组，而E2水平则显著低于非FBOO组。轻度梗阻组TG、TCH和APOB水平显著低于中重度梗阻组，差异有统计学意义（P<0.05）；轻度梗阻组FSH、LH和T水平显著低于中重度梗阻组，而E2水平则显著高于中重度梗阻组，差异有统计学意义（P<0.05）。梗阻程度与FSH、LH、T、TG、TCH和APOB水平显著正相关（P<0.05），随着FSH、LH、T、TG、TCH和APOB水平的增加，梗阻程度越严重；梗阻程度与E2水平显著负相关（P<0.05），随着E2水平的降低，梗阻程度越重。结论：随着梗阻程度的加重，雌激素水平逐渐下降，FSH水平、LH水平上升，T水平有上升趋势。雌激素的降低导致TCH、TG、TCH、APOB水平有上升的趋势。

【关键词】 女性膀胱出口梗阻； 性激素； 血脂； 相关性

doi：10.14033/j.cnki.cfmr.2017.11.002 文献标识码 A 文章编号 1674-6805（2017）11-0003-03

The Relationship between the Female Bladder Outlet Obstruction and the Levels of Hormones and Blood Lipids/TANG Li-feng，YANG Zhi-gang.//Chinese and Foreign Medical Research，2017，15（11）：3-5

【Abstract】 Objective：To investigate the effect of female hormone and blood lipid level on the female bladder outlet obstruction.Method：A total of 70 cases of perimenopausal and postmenopausal female patients in our hospital were collected from January 2015 to December 2016.30 patients were diagnosed as female bladder outlet obstruction.According to the calculation of Blaivas-Groutz nomogram，the patients were categorized into slight obstruction group（n=16） and moderate or heavy obstruction group（n=14）.The patients of female bladder outlet obstruction were tested with the blood serum sex hormone and blood lipid level.The others were tested with sex hormone.Result：The level of FSH，LH and E2 in FBOO group and non FBOO group，the difference were statistically significant（P<0.05）.The levels of LH and FSH in FBOO group were significantly higher than that in non FBOO group，but E2 level was significantly lower than that in non FBOO group.TG，TCH and APOB level differences were statistically significant（P<0.05）.TG，TCH and APOB in mild obstruction level were significantly lower than those in severe obstruction group.Mild obstruction group and severe obstruction group had statistically significant difference in FSH，LH，E2 and T level（P<0.05）.FSH，LH and T levels in mild obstruction group were significantly lower than those in severe obstruction group，while the level of E2 was significantly higher than that in the mild obstruction group.There were significant positive correlation with the degree of obstruction of FSH，LH，T，TG，TCH and APOB level（P<0.05），with the increase of FSH，LH，T，TG，TCH and APOB levels，the more serious the degree of obstruction.There was significant negative correlation with decreased E2 level，more the degree of obstruction heavy.Conclusion：With the degree of obstruction rise，estrogen gradually decreases，FSH level，LH level increase，T level increases.The decrease of estrogen leads to the rise of TCH，TG，TCH and APOB level.

【Key words】 Female bladder outlet obstruction； Sex hormones； Blood lipid； Correlation

First-authors address：Baotou Medical College，Baotou 014040，China

女性膀胱出口梗阻（FBOO）是女性从膀胱颈部到尿道外口由不同发病机制、不同原因引起任何管腔狭窄使排尿阻力增加造成的排尿困难[1]。患者多数因不同程度排尿不尽感及淋漓不尽、排尿不畅的症状就诊，常见于反复泌尿系感染、多产史的围绝经期及绝经后女性。女性尿道周围腺体与男性同源，围绝经期及绝经后女性可因激素改变而致尿道周圍腺体增生，产生与男性前列腺增生相同的症状[2]。FBOO的病因有很多，包括神经系统疾病（如神经源性膀胱、糖尿病和脊髓损伤等）和非神经源性疾病，即解剖性梗阻和功能性梗阻[3]。

1 资料与方法

1.1 一般资料

本研究收集笔者所在医院2015年1月-2016年12月就诊的围绝经期及绝经后FBOO患者30例（FBOO组），均诊断为女性膀胱出口梗阻且为围绝经期及绝经后患者。膀胱镜检查示：膀胱小梁，假性憩室，膀胱颈后唇堤坝样抬高，平置膀胱看不到三角区，膀胱颈环形缩窄、僵硬。尿动力示：高动力低尿流率。……