孙妍　王英　陈晓晶　李雪春　李德林　臧敏

[摘要] 目的 探讨血清25-羟维生素D3水平与婴儿喘息的关系。 方法 选取2015年12月～2016年12月间本院收治的下呼吸道感染患儿166例为研究对象，采用酶联免疫吸附法检测54例婴儿喘息患儿、47例毛细支气管炎患儿、65例普通肺炎患儿的血清25-羟维生素D3水平，并对患儿进行呼吸道病原学及血过敏原检测。对照组为同期在儿保门诊体检的42例健康婴儿。 结果 （1）婴儿喘息组、毛细支气管炎组及普通肺炎组血清25-羟维生素D3浓度均明显低于健康对照组婴儿，差异有统计学意义；普通肺炎组及毛细支气管炎组血清25-羟维生素D3水平明显高于婴儿喘息组，差异均有统计学意义；普通肺炎组血清25-羟维生素D3水平高于毛细支气管炎组，差异有统计学意义；（2）普通肺炎组与毛细支气管炎组、婴儿喘息组比较，病毒阳性率差异均有统计学意义；毛细支气管炎组与婴儿喘息组比较，差异无统计学意义。三组间血过敏原差异无统计学意义。 结论 病毒感染是婴儿喘息发生的主要因素，而维生素 D不足可能增加婴儿喘息发生的风险。

[关键词] 血清 25-羟维生素D3；婴儿喘息；病毒感染；过敏原

[中图分类号] R171 [文献标识码] A [文章编号] 1673-9701（2017）14-0025-03

[Abstract] Objective To investigate the relationship between serum 25-hydroxy vitamin D3 and infant wheezing. Methods A total of 166 children with lower respiratory tract infection from December 2015 to December 2016 were enrolled in this study. The level of serum 25-hydroxy vitamin D3 in 54 infants with wheezing， 47 infants with bronchiolitis and 65 infants with common pneumonia were examined by enzyme-linked immunosorbent assay（ELISA）. And respiratory pathology and blood allergy were detected in children. A total of 42 healthy infants in the outpatient care were selected as the control group in the same period. Results （1） Serum 25-hydroxy vitamin D3 concentration in infant wheezing group， bronchiolitis group and common pneumonia group was significantly lower than that in healthy control group， and the difference was statistically significant. The serum 25-hydroxy vitamin D3 level in common pneumonia group and bronchiolitis group was significant higher than that in the wheezing group， and the difference was statistically significant. The serum 25-hydroxy vitamin D3 level in common pneumonia group was significant higher than that in the bronchiolitis group， and the difference was statistically significant.（2）There was significant difference in the positive rate of virus between the common pneumonia group and the bronchiolitis group， the infant wheezing group. There was no significant difference in the positive rate of virus between the bronchiolitis group and the infant wheezing group. And there was no significant difference in the blood allergen in the infant wheezing group， bronchiolitis group and common pneumonia group. Conclusion Virus infection is a major factor in infant wheezing， and vitamin D deficiency may increase the risk of infant wheezing.

[Key words] Serum 25-hydroxy vitamin D3； Infant wheezing； Virus infection； Allergens

維生素D（Vitamin D）是人体一种必需的脂溶性类固醇衍生物，目前国内外有许多研究均发现骨骼畸形、骨质疏松、癌症、自身免疫性疾病、感染性疾病、心血管疾病、皮肤病、肾脏疾病等多系统疾病与维生素 D缺乏均密切相关[1]。国外学者Camargo Jr CA等[2，3]报道，产妇在孕期摄入维生素D的水平与后代喘息、儿童哮喘的发生有关。……