周利平　陈娟英　沈华　任黎刚　腾腾

[摘要] 目的 探討前列康片联合头孢呋辛酯片对慢性前列腺炎患者血清细胞因子的影响及疗效。 方法 选择我院2013年1月～2015年12月接诊的148例慢性前列腺炎患者，随机分成两组，观察组74例患者给予前列康片联合头孢呋辛酯片治疗，对照组74例患者给予头孢呋辛酯片治疗，通过比较两组患者临床症状改善、中医症候及前列腺液中分泌型免疫球蛋白A（SIgA）、血管细胞粘附分子-1（VCAM-1）及血清VCAM-1变化，讨论前列康片联合头孢呋辛酯片对慢性前列腺炎患者血清细胞因子的影响及疗效。 结果 观察组临床疗效总有效率94.59%，高于对照组临床疗效总有效率78.38%，两组比较差异有统计学意义（P<0.05）。两组治疗前NIH-CPSI指数没有明显差异，两组治疗后NIH-CPSI指数均有显著改善，观察组的改善更优于对照组，两组比较差异有统计学意义（P<0.05）。两组治疗前中医证候积分没有明显区别，治疗后均有所减少，观察组的减少大于对照组（t=3.0447，P=0.0033）。观察组中医证候疗效总有效率91.89%，高于对照组中医证候疗效总有效率72.97%，差异有统计学意义（P<0.05）。两组治疗前前列腺液中SIgA、VCAM-1及血清VCAM-1均无明显差异，治疗后均有降低，观察组的改善更优于对照组，两组比较差异有统计学意义（P<0.05）。 结论 前列康片联合头孢呋辛酯片的治疗方法，能有效调节血清细胞因子控制炎症，对慢性前列腺炎治疗起到较好效果，值得临床应用。

[关键词] 前列康片；头孢呋辛酯片；慢性前列腺炎；血清细胞因子

[中图分类号] R697.3 [文献标识码] A [文章编号] 1673-9701（2017）14-0028-04

[Abstract] Objective To investigate the influence and therapeutic effect of Qianliekang tablets combined with cefuroxime axetil tablets on serum cytokines in patients with chronic prostatitis. Methods 148 patients with chronic prostatitis who were admitted to our hospital from January 2013 to December 2015 were selected and randomly divided into two groups. The patients（n=74） in the observation group were treated with Qianliekang tablets combined with cefuroxime axetil tablets and 74 patients in the control group were treated with cefuroxime axetil tablets.The influence and therapeutic effect of Qianliekang tablets combined with cefuroxime axetil tablets on serum cytokines in patients with chronic prostatitis were explored by comparing the clinical symptoms improvement， Chinese medicine symptoms and the changes of secretory immunoglobulin A （SIgA），vascular cell adhesion molecule-1 （VCAM-1） and serum VCAM-1 between the two groups. Results The clinical total effective rate was 94.59% in the observation group， higher than 78.38% of the control group. The difference was statistically significant（P<0.05）. There was no significant difference in NIH-CPSI index between the two groups before treatment， and the NIH-CPSI index was significantly improved in both groups after treatment. The improvement of the observation group was better than that of the control group， and the difference between the two groups was statistically significant（P<0.05）. There was no significant difference in traditional Chinese medicine syndrome score between the two groups before treatment， and the score was reduced after treatment. The reduction in the observation group was greater than that in the control group（t=3.0447， P=0.0033）. The total effective rate of traditional Chinese medicine syndrome was 91.89% in the observation group， which was higher than that in the control group（72.97%）， and the difference was statistically significant（P<0.05）. There was no significant differences in SIgA，VCAM-1 in prostatic fluid and serum VCAM-1 between the two groups before treatment，and the SIgA，VCAM-1 in prostatic fluid and serum VCAM-1were reduced after treatment.The improvement of the observation group was better than that of the control group，and the difference between the two groups was statistically significant（P<0.05）. Conclusion The treatment of Qianliekang tablets combined with cefuroxime axetil tablets can effectively regulate the serum cytokines to control inflammation，which has a good effect on the treatment of chronic prostatitis，and is worthy of clinical application.

[Key words] Qianliekang tablets； Cefuroxime axetil tablets； Chronic prostatitis； Serum cytokines

慢性前列腺炎是泌尿生殖疾病的一种，约有一半男性会在某个时期受其困扰，严重影响男性健康[1-2]。慢性前列腺炎可分为慢性细菌性前列腺炎和慢性非细菌性前列腺炎，细菌性前列腺炎的病因主要为葡萄球菌属感染，临床多表现为反复发作的尿路感染[3-4]。非细菌性前列腺炎致病因较为复杂，由多种原因共同导致，临床多表现为骨盆附近疼痛。慢性前列腺炎治疗时间长，久治不愈可能会导致患者生活质量下降，影响患者身体及心理健康。针对性治疗慢性前列腺炎，不少药物取得了一定的成效，包括头孢呋辛酯片、前列舒通及宁泌泰胶囊等。有学者研究发现[5-6]，中医药治疗慢性前列腺炎有较好疗效，其中采用前列康片治疗慢性前列腺炎更是拥有独特优势。……