王珮珮　董加洪　叶文成　李俊

[摘要] 目的 探讨牙周病戴自锁托槽矫治器正畸治疗对患者龈沟液中细胞因子的影响。 方法 选择牙周病戴托槽矫治器正畸治疗患者120例，随机分为观察组和对照组，观察组患者戴自锁托槽矫治器正畸治疗，对照组戴传统托槽矫治器正畸治疗。测量治疗前后龈沟液含量及龈沟液中前列腺素E2（prostaglandin E2，PGE2）、肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）和白细胞介素-1β（Interleukin-1β，IL-1β）水平。 结果 观察组和对照组治疗后3 d、治疗后1周、治疗后2周、治疗后4周龈沟液含量、PGE2水平、TNF-α水平、IL-1β水平高于治疗前（P<0.05），观察组治療后1周、治疗后2周、治疗后4周龈沟液含量、PGE2水平、TNF-α水平、IL-1β水平低于对照组（P<0.05）。 结论 牙周病戴托槽矫治器正畸治疗后龈沟液含量、PGE2水平、TNF-α水平、IL-1β水平升高，自锁托槽矫治器正畸治疗有利于降低正畸治疗后龈沟液含量和细胞因子水平。

[关键词] 牙周病；自锁托槽矫治器；正畸；龈沟液；细胞因子

[中图分类号] R783.5 [文献标识码] A [文章编号] 1673-9701（2017）14-0015-04

[Abstract] Objective To investigate the effect of wear self-locking bracketsorthodontic treatment on the cytokines in the gingival crevicular fluid of patients with periodontal disease. Methods 120 periodontal diseasepatients with orthodontic treatment were selected， and were randomly divided into observation group and control group. The patients in the observation group were treated with self-locking brackets orthodontic treatment. The patients in the control group received traditional orthodontic treatment of orthotopic appliance. The gingival crevicular fluid content and the levels of prostaglandin E2（PGE2）， tumor necrosis factor-α（TNF-α） and interleukin-1β（IL-1β） in the gingival crevicular fluid before and after treatment were measured. Results The levels of gingival crevula fluid， PGE2， TNF-α and IL-1 in the observation group and the control group at 3 days after treatment， 1 week after treatment， 2 weeks after treatment and 4 weeks after treatment were higher than those before treatment（P<0.05）， the levels of gingival crevicular fluid， PGE2， TNF-α and IL-1β in the observation group 1 week after treatment， 2 weeks after treatment and 4 weeks after treatment were lower than those in the control group（P<0.05）. Conclusion The level of gingival crevicular fluid， PGE2， TNF-α and IL-1β periodontal disease patients after orthodontic treatment are increased. Self-locking brachial orthodontic treatment is beneficial to reduce the level of gingival crevicular fluid and cytokine after orthodontic treatment.

[Key words] Periodontal disease； Self-locking brachial appliance； Orthodontic； Gingival crevicular fluid； Cytokines

牙周病是口腔常见疾病之一，为进展性、慢性疾病，由多种因素引起，牙周病患者牙周支持组织少，常出现错颌畸形等，正畸治疗可以改善牙周状况，减轻牙龈炎症，增加牙齿稳定性，使牙周袋变浅，提升患者的牙齿功能，使牙齿看起来更美观[1]。但正畸治疗过程中牙周组织出现改建，引起机体产生一定程度的炎症反应[2，3]，不同的正畸矫治器对牙周组织改建的影响不同。自锁托槽矫治器摩擦力小、省时省力、操作简单，受到正畸医生的青睐[4，5]。本文对牙周病患者采用自锁托槽矫治器正畸治疗，观察其对患者龈沟液含量及龈沟液中细胞因子的影响，现报道如下。

1 资料与方法

1.1 一般资料

选择丽水市中心医院口腔科2009年7月～2016年6月牙周病戴托槽矫治器正畸治疗患者120例，根据随机数字法分为观察组和对照组，每组60例。……