于祥+罗佳+陈琪玮+曲华+任灵

[摘要]目的 探討门诊反复呼吸道感染患儿14种食物不耐受的检测结果及意义，为儿童反复呼吸道感染的病因诊断、预防和治疗提供新的实验室参考依据。方法 选择2013年9月～2014年9月在我院儿科门诊就诊的反复呼吸道感染患儿72例，定为实验组，健康对照组90例为我院儿童保健门诊健康体检儿童，对两组儿童进行14种食物不耐受（食物过敏原特异性IgG抗体）检测，并进行统计学分析。同时根据检测结果采取饮食控制、定期随访，观察饮食控制后反复呼吸道感染发病改善情况。结果 实验组儿童血清食物特异性IgG总阳性率为63.9%，高于健康对照组的32.2%，两组比较差异有统计学意义（P<0.01），其中实验组46例食物特异性IgG阳性患儿采取饮食控制后随访1年，29例患儿未再发生反复呼吸道感染。结论 门诊反复呼吸道感染与食物不耐受存在相关性，进行饮食控制后，可减少反复呼吸道感染的发病，食物不耐受检测在儿童反复呼吸道感染防治中有积极临床意义。

[关键词]反复呼吸道感染；儿童；食物不耐受

[中图分类号] R725 [文献标识码] A [文章编号] 1674-4721（2016）12（b）-0093-04

Detection and meaning of food intolerance in recurrent respiratory tract infection children patients in outpatient

YU Xiang LUO Jia CHEN Qi-wei QU Hua REN Ling

Department of Pediatrics，the Second Hospital Affiliated to Shenyang Medical College in Liaoning Province，Shenyang 110035，China

[Abstract]Objective To explore the detection results and meaning for 14 kinds of food intolerance of recurrent respiratory tract infection children patients in outpatient and to provide new laboratory reference for etiological diagnosis，prevention and treatment for recurrent respiratory tract infection.Methods 72 children with recurrent respiratory tract infection treated by pediatric outpatient in our hospital from September 2013 to September 2014 were selected and were selected as experimental group.90 healthy children from child health clinic of our hospital were selected as control group.14 kinds of food intolerance detection （food allergen specific IgG antibody） were conducted in two groups and statistical analysis was conducted.Diet control and regular follow up were adopted according to examination results.The improvement situation of recurrent respiratory tract infection morbidity after diet control was observed.Results The total positive rate of serum food specific IgG antibody in experimental group （63.9%） was higher than that in health control group （32.2%） and the difference between two groups was statistical significance （P<0.01）.In the experimental group，46 cases of food specific IgG positive children were followed up for one year after diet control，there was no recurrent respiratory infection occurred in 29 children.Conclusion Outpatient recurrent respiratory tract infection has relationship with food intolerance.Diet control can decrease the morbidity of recurrent respiratory tract infection.Food intolerance detection has positive clinical value in prevention and treatment of recurrent respiratory tract infection in children.

[Key words]Recurrent respiratory tract infection；Children；Food intolerance

儿童反复呼吸道感染是儿科常见病，病情反复迁延，影响小儿生长发育，给家庭和社会带来巨大经济负担，故有关儿童反复呼吸道感染的病因学一直是临床研究热点，其致病因素复杂，涉及环境和机体自身等多重因素，如免疫功能低下、先天畸形、营养物质缺乏、慢性疾病、护理不当等[1]。近年来随着食物过敏、食物不耐受研究的深入，有学者发现食物过敏原特异性IgG抗体升高可能与反复呼吸道感染具有相关性[2]，而其他科如消化科、皮肤科的学者则发现某些消化系统疾病、变应性皮炎等与食物不耐受有关，如果采用禁食轮替治疗，会收到很好的效果[3-4]。本研究将在我院儿科……