赵静+郭端英+刘阳

【摘要】 目的 探究左氧氟沙星联合妇科千金片对慢性盆腔炎患者炎性因子的影响。方法 110例慢性盆腔炎患者， 随机分为观察组和对照组， 各55例。观察组患者给予左氧氟沙星联合妇科千金片治疗， 对照组患者仅给予左氧氟沙星治疗。比较两组疗效。结果 观察组总有效率为92.7%， 显著高于对照组的72.7%， 差异具有统计学意义（P<0.05）；治疗后， 观察组白带增多、子宫或附件压痛、盆腔积液发生率均显著低于对照组， 差异具有统计学意义（P<0.05）；治疗后， 观察组白细胞介素（IL）-2、IL-4、IL-10水平均显著高于对照组， 肿瘤坏死因子-α（TNF-α）水平显著低于对照组， 差异具有统计学意义（P<0.05）。结论 采用左氧氟沙星联合妇科千金片治疗慢性盆腔炎， 可显著改善临床症状， 抑制盆腔慢性炎症， 具有良好疗效与安全性， 值得临床推广采用。

【关键词】 左氧氟沙星；妇科千金片；慢性盆腔炎；炎性因子

DOI：10.14163/j.cnki.11-5547/r.2017.05.055

Influence by levofloxacin combined with Fuke Qianjin tablets on inflammatory factors in chronic pelvic inflammatory disease patients ZHAO Jing， GUO Rui-ying， LIU Yang. Department of Gynecology， Shenzhen City Longhua New District Peoples Hospital Longyuan Community Health Center， Shenzhen 518109， China

【Abstract】 Objective To investigate influence by levofloxacin combined with Fuke Qianjin tablets on inflammatory factors in chronic pelvic inflammatory disease patients. Methods A total of 110 patients with chronic pelvic inflammatory disease were randomly divided into observation group and control group， with 55 cases in each group. The observation group received levofloxacin combined with Fuke Qianjin tablets for treatment， and the control group received levofloxacin for treatment alone. Curative effects were compared between the two groups. Results The observation group had obviously higher total effective rate as 92.7% than 72.7% in the control group， and their difference had statistical significance （P<0.05）. After treatment， the observation group had much lower incidences of leukorrhagia， uterine and appendages pressing pain， and pelvic effusion than the control group， and the difference had statistical significance （P<0.05）. After treatment， the observation group had much higher interleukin （IL）-2， IL-4 and IL-10 levels than the control group， and it had lower tumor necrosis factor-α （TNF-α） level than the control group. The difference had statistical significance （P<0.05）. Conclusion Combination of levofloxacin and Fuke Qianjin tablets in treating chronic pelvic inflammatory disease can remarkably improve clinical symptoms and inhibit chronic pelvic inflammation. This method contains excellent curative effect and safety， and it is worth clinical promotion and application.

【Key words】 Levofloxacin； Fuke Qianjin tablets； Chronic pelvic inflammatory disease； Inflammatory factors

慢性盆腔炎多針对非绝经期活跃期女性， 为女性盆腔腹膜、周围结缔组织、女性生殖内器官内慢性炎症的总称。通常患者均表现为低热、腹痛、下腹坠痛、阴道分泌物较多、盆腔包块等， 甚至可引发不孕症、异位妊娠[1-4]。盆腔炎较难治愈， 且复发率较高， 对患者身心健康产生严重影响[5]。本研究中55例观察组慢性盆腔炎患者采用左氧氟沙星联合妇科千金片治疗， 效果显著。现报告如下。

1 资料与方法

1. 1 一般资料 选择2014年9月～2016年9月本院及龙岗中心医院收治的110例慢性盆腔炎患者为研究对象， 年龄19～46岁， 平均年龄（31.3±5.7）岁， 病程3个月～4年， 平均病程（1.5±0.9）年。全部患者均符合相关盆腔炎诊断标准， 且经B超与血常规检查， 排除其他妇科疾病， 确诊为盆腔炎。排除妊娠、消化道出血、急腹症患者， 严重心、肝、肾疾病患者， 妇科肿瘤、子宫内膜异位症患者。随机将患者分为观察组与对照组， 各55例。

1. 2 方法 对照组患者给予左氧氟沙星治疗， 采用100 ml 0.3%左氧氟沙星注射液， 2次/d， 静脉滴注。观察组在对照组基础上联合妇科千金片治疗， 6片 /次， 3次/d， 温水口服。……