王俊丽

【摘要】 目的 分析胃乐新联合兰索拉唑肠溶胶囊治疗消化性胃溃疡的效果。方法 89例消化性胃溃疡患者， 将其随机分为对照组（43例）与观察组（46例）。对照组给予胃乐新治疗， 观察组在对照组基础上加用兰索拉唑治疗。比较两组治疗效果。结果 治疗前两组腹部隐痛、嗳气反酸、恶心呕吐、腹泻腹胀积分比较差异均无统计学意义（P>0.05）；治疗后两组各症状积分均较治疗前明显下降， 且观察组低于对照组， 差异均具有统计学意义（P<0.05）。对照组不良反应发生率9.30%略低于观察组13.04%， 但差异无统计学意义（P>0.05）。结论 以胃乐新与兰索拉唑联合治疗消化性胃溃疡效果显著， 能有效减轻患者溃疡症状， 且不良反应发生率低， 安全性高。

【关键词】 消化性胃溃疡；胃乐新；兰索拉唑

DOI：10.14163/j.cnki.11-5547/r.2017.05.042

Effect analysis of Weilexin combined with lansoprazole enteric-coated capsules in the treatment of pepticgastriculcer WANG Jun-li. Department of Gastroenterology， Jinan City First Peoples Hospital， Jinan 250002， China

【Abstract】 Objective To analyze the effect of Weilexin combined with lansoprazole enteric-coated capsules in the treatment of pepticgastriculcer. Methods A total of 89 pepticgastriculcer patients were randomly divided into control group （43 cases） and observation group （46 cases）. The control group received Weilexin for treatment， and the observation group received lansoprazole on the basis of the control group. Treatment effect was compared in two groups. Results There was no statistically significant difference in abdominal dull pain， belching and acid regurgitation， nausea and vomiting， diarrhea and abdominal distension integral before treatment between two groups （P>0.05）. Both groups had obvious decline in each symptom integral after treatment than before treatment， and the observation group had lower integral than the control group. Their difference had statistical significance （P<0.05）. The control group had incidence of adverse reactions as 9.30%， which was lower than 13.04% in the observation group， but the difference had no statistical significance （P>0.05）. Conclusion Combination of Weilexin and lansoprazole shows significant effect in the treatment of pepticgastriculcer， and it can effectively relieve ulcer symptoms in patients with low incidence of adverse reactions and high safety.

【Key words】 Pepticgastriculcer； Weilexin； Lansoprazole

消化性胃溃疡是消化科常见炎症疾病， 主要由胃酸及胃蛋白酶消化自身黏膜所致， 对胃肠功能和相关脏器存在较大影响[1-5]。胃溃疡发生原因与患者不合理饮食和生活习惯有关， 如长期酗酒、抽烟、喝茶或咖啡等均易引发胃溃疡[2]。目前， 临床治疗此病多以药物治疗为主， 能有效降低胃酸pH值， 延缓溃疡， 保护黏膜组织。现常用药物有胃乐新、兰索拉唑、奥美拉唑、康复新液等[6-8]。本研究现就胃乐新与兰索拉唑联合治疗消化性胃溃疡取得的效果进行分析， 现报告如下。

1 资料与方法

1. 1 一般资料 选取2016年5～12月治疗的89例消化性胃溃疡患者， 将其随机分为对照组（43例）和观察组（46例），

对照组中男25例， 女18例；年龄25～67岁， 平均年龄（45.89±7.04）岁；溃疡部位：肠胃部16例、十二指肠20例、复合型7例。观察组中男26例， 女20例；年……