李国泉+邓盈军+聂国能+陈明春

【摘要】目的：观察氩气高频电刀联合干扰素治疗尖锐湿疣的疗效以及对淋巴细胞趋化（LTN）因子和白细胞介素-17（IL-17）的影响。方法：将本院收治的尖锐湿疣患者96例参照数字法随机分为治疗组和对照组，两组各48例；对照组给予氩气高频电刀治疗，同时口服蒲地蓝消炎胶囊，3粒/次，4次/d；治疗组在对照组基础上采用重组人干扰素α-2b肌内注射治疗，1×106IU/d，3次/d；两组均连续治疗4周。分析两组治疗后临床疗效；比较两组不良反应和复发情况；检测两组血清LTN和IL-17。结果：治疗组患者临床总有效率为89.58%，对照组为66.67%，治疗组明显高于对照组（P<0.05）；两组治疗期间不良反应发生比较均无显著差异（P>0.05）；对照组在治愈基础上有7例复发，治疗组复发3例，治疗组明显低于对照组（P<0.05）；治疗组治疗后2周和4周，患者血清LTN水平明显高于同期对照组，IL-17明显低于同期对照组，比较差异有统计学意义（P<0.01）。结论：氩气高频电刀联合干扰素治疗尖锐湿疣的疗效显著，不良反应少，复发率低，提高患者血清LTN水平和降低血清IL-17水平可能与上述疗效相关。

【关键词】氩气高频电刀；干扰素；尖锐湿疣；淋巴细胞趋化因子；白细胞介素-17

Curative effect of argon high-frequency electrocautery combined with interferon in treating verruca acuminate and influences on lymphotactin and interleukin-17LI Guoquan1， DENG Yingjun1， NIE Guoneng1， CHEN Mingchun2. 1. Dermatology & STD Department， Jiangmen Second Peoples Hospital， Jiangmen 529030， Guangdong， China； 2. Dermatology & STD Department， The Second Hospital Affiliated to Sun Yat-sen University， Guangzhou 510120， Guangdong， China

【Abstract】Objectives： To observe the curative effect of argon high-frequency electrocautery combined with interferon in treating verruca acuminate and influences on lymphotactin and interleukin-17. Methods： According to the random number table method， 96 patients with verruca acuminate in our hospital were randomly divided into control group （48 cases） and treatment group （48 cases）. Patients in control group were orally treated by argon high-frequency electrocautery and Pudilan Xiaoyan capsule （3 capsules/time and q6h）. On such basis， treatment group was treated by recombination interferon α2b by intramuscular injection （1×106IU/d， tid）. The therapy courses were 4 weeks in both groups. Clinical effects were analyzed between both groups after treatment. Adverse reactions and recurrences were compared in two groups. Serum LTN and IL-17 were detected for both groups. Results： The total effective rate for treatment group was 89.58%， which was superior to control group of 66.67%（P<0.05）. Adverse reactions of two groups had no significant differences （P>0.05）. There were 7 cases of recurrences in control group， which was less to treatment group of 3 cases （P<0.05）. Serum LTN level of treatment group was obviously higher those of control group， while IL-17 was evidently lower， with statistic differences after 2 and 4 weeks treatment （P<0.01）. Conclusion： Argon high-frequency electrocautery combined with interferon in treating verruca acuminate has a striking effect with rare adverse reactions and low recurrence rates， and its role may be related with increasing serum LTN and decreasing IL-17.endprint

【Key words】Argon high-frequency electrocautery； Interferon； Verruca acuminate； Lymphotactin； Interleukin-17

【中图分类号】R752.5+3【文献标志码】A

尖锐湿疣属性传播疾病，由人乳头瘤病毒（HPV）感染引起的生殖器、会阴以及肛门及周围部位的表皮增殖性病变。由于其病变部位的特殊性，对患者的生活质量和心身健康构成严重威胁[1]。调查显示，尖锐湿疣的发病率呈逐年上升趋势，且具有生长速度较快、复发率高等特点，给临床治疗带来极大挑战[2]。目前，临床治疗尖锐湿疣的疗法较多，如口服药物、手术切除以及化学治疗等，但疗效欠佳，治愈后复发率高[3]。

研究[4，5]发现，在尖锐湿疣治疗中，抗HPV 感染是其治本疗法。为了达到标本兼治的目的，本研究在干扰素抗HPV治疗基础上，给予氩气高频电刀根除治疗，取得良好治疗效果；……