椰慧楠 李晓东 秦宝丽 等

[摘要] 目的 研究乳腺癌患者采用分子靶向治疗的临床效果。 方法 选取2011年10月～2014年5月辽宁省肿瘤医院收治的120例乳腺癌患者作为研究对象，根据随机数字表法将患者随机分为对照组和研究组，各60例，对照组采取药物保守治疗方法，研究组采取分子靶向治疗方法。统计分析两组患者的临床疗效以及复发率。 结果 研究组有效率高达85.00%，明显高于对照组的56.67%，差异有统计学意义（P < 0.05）。研究组治疗后复发率为10.00%，明显低于对照组的31.67%，差异有统计学意义（P < 0.05）。 结论 针对乳腺癌患者采取分子靶向治疗临床效果确切，其可以明显提高治疗有效率，降低复发率，并且毒性小，值得临床推广应用，对于具备分子靶向治疗条件的乳腺癌患者应该是首选的治疗方案。

[关键词] 乳腺癌；分子靶向治疗；疗效

[中图分类号] R737.9 [文献标识码] A [文章编号] 1673-7210（2016）02（b）-0118-04

Clinical study of molecular targeted therapy in patients with breast cancer

YE Huinan1 LI Xiaodong2 QIN Baoli1 WANG Zhongmiao1

1.The Second Department of Internal Medicine， Liaoning Cancer Hospital， Liaoning Province， Shenyang 110032， China； 2.Institute of Cancer Stem Cell， Dalian Medical University， Liaoning Province， Dalian 110044， China

[Abstract] Objective To study the clinical effect of molecular targeted therapy in patients with breast cancer. Methods One hundred and twenty cases of patients with breast cancer admitted to Liaoning Cancer Hospital from October 2011 to May 2014 were selected as research objects， and the patients were randomly divided into control group and study group by random number table， with 60 cases in each group. The control group was taken drugs conservative treatment， the study group was taken molecular targeted therapy. The clinical therapeutic effect and recurrence rate of the two groups were calculated and analyzed. Results The effective rate of study group reached to 85.00%， which was significantly higher than that of control group （56.67%）， the difference was statistically significant （P < 0.05）. After treatment， the recurrence rate of study group was 10.00%， which was significantly lower than that of control group （31.67%）， the difference was statistically significant （P < 0.05）. Conclusion Molecular targeted therapy in patients with breast cancer has exact curative effect， which can significantly improve effective rate and reduce the recurrence rate and the toxicity is small， it is worthy of clinical promotion and application. Molecular targeted therapy should be the preferred therapeutic schedule for patients with breast cancer.

[Key words] Breast cancer； Molecular targeted therapy； Effect

乳腺癌作為全世界最常见的恶性肿瘤，全球每年新增患者约有138万例，并且约有46万例因其死亡，病死率已经占据女性恶性肿瘤的首位[1-2]。虽然治疗乳腺癌的手段众多，但靶向治疗已经成为最主要的治疗方法之一。按照靶向药物作用机制的不同，将其分为两大类：一类为针对靶向肿瘤细胞药物，比如抗人表皮生长因子受体2（HER2）靶向药物、CDK4/6抑制剂、PI3K/AKT/mTOR抑制剂及多聚腺苷二磷酸核糖聚合酶（PARP）抑制剂等；另一类则为针对靶向肿瘤微环境药物，比如抗血管新生的靶向药物等[3-6]。临床研究提示，作用靶点的不同，靶向药物所起的临床疗效、在临床应用过程中面临的问题和解决的措施都有所不同，靶向药物所起到的临床疗效主要依据其在细胞内作用的机制[7-8]。本研究选取120例乳腺癌患者进行研究，针对患者采取分子靶向治疗，分析其临床疗效，现将具体的研究过程报道如下：

1 资料与方法

1.1 一般资料