张纪良　青晓燕　兰　曦成都市第七人民医院肿瘤内科，四川成都　610021

重组人白介素-11治疗鼻咽癌放化疗所致急性口腔黏膜炎疗效观察

张纪良青晓燕兰曦
成都市第七人民医院肿瘤内科，四川成都610021

目的观察重组人白介素-11（IL-11）治疗鼻咽癌放化疗所致急性口腔黏膜炎的疗效。 方法将64例在治疗过程中出现2级及以上的急性口腔黏膜炎的鼻咽癌患者随机分为观察组和对照组各32例；对照组以地塞米松、利多卡因及庆大霉素溶液漱口方法治疗，观察组在此基础上加用重组人白介素-11治疗。治疗2周后行疗效评价，同时观察口腔疼痛缓解情况及两组生活质量改善情况。 结果观察组的急性口腔黏膜炎有效率为90.63%，对照组为68.75%，两组比较差异有统计学意义（χ2=4.73，P=0.03）；观察组口腔疼痛缓解的有效率为87.50%，对照组为59.38%，差异具有统计学意义（χ2=6.488，P=0.022）；观察组Karnofsky评分提高率为59.38%，明显高于对照组的31.25%（χ2=5.107，P=0.044）。结论联合重组人白介素-11治疗鼻咽癌放化疗所致口腔黏膜炎疗效更好，能有效减少口腔疼痛和改善生活质量，且使用方便，值得临床推广。

重组人白介素-11；鼻咽癌；放化疗；急性口腔黏膜炎

［Abstract］Objective To observe the efficacy of recombinant human inter1eukin-11（IL-11）in treatment of acute ora1 mucositis re1ated with nasopharyngea1 carcinoma chemoradiotherapy.Methods 64 patients with 1eve1 2 and above acute ora1 mucositis were divided into observation group（n=32）and contro1 group（n=32）at random.Contro1 group was treated by garg1es with dexamethasone，1idocaine and gentamicin，and combined use of recombinant human IL-11 for observation group.The therapeutic effects were eva1uated after two weeks.At the same time，the ora1 pain re1ief effect and the improvement of qua1ity of 1ife were eva1uated.Results The tota1 effective rate of acute ora1 mucositis in observation group was 90.63%，and the contro1 group was 68.75%.The data of the two groups had significant difference（χ2=4.73，P=0.03）.The effective rate of ora1 pain re1ief in observation group was 87.50%and 59.38%in the contro1 group，the two groups had statistica1 differences（χ2=6.488，P=0.022）.And there was significant differences in the improvement of Karnofsky as we11（59.38%vs 31.25%，χ2=5.107，P=0.044）.Conclusion Combined use of recombinant human IL-11 can achieve better therapeutic effects in treatment of acute ora1 mucositis caused by concurrent radiochemotherapy.At the same time it can effective1y reduce ora1 pain and improve the qua1ity of 1ife.It is convenient to use，and this method is worth popu1arizing in c1inica1 practice

［Key words］Recombinant human inter1eukin-11；Nasopharyngea1 carcinoma；Chemoradiotherapy；Acute ora1 mucositis

鼻咽癌是临床常见的恶性肿瘤，放射治疗是其重要治疗手段。同步放化疗可以提高鼻咽癌治疗的疗效，但相关不良反应也相应增加。急性口腔黏膜损伤是鼻咽癌放化疗中常见的并发症，常常造成治疗延期，部分患者甚至因为严重的口腔黏膜损伤而中断治疗，导致疗效欠佳。我科在患者发生急性口腔黏膜炎时常采用措施是配置地塞米松、利多卡因加庆大霉素生理盐水溶液漱口处理。……