袁一加　龚　唯.重庆市公共卫生医疗救治中心结核一科，重庆　400036；.重庆市渝北区人民医院急诊科，重庆　400036

左氧氟沙星联合抗结核方案治疗肺结核临床效果

袁一加1龚唯2
1.重庆市公共卫生医疗救治中心结核一科，重庆400036；2.重庆市渝北区人民医院急诊科，重庆400036

目的探讨左氧氟沙星联合抗结核方案治疗肺结核临床效果。 方法选择本院2013年1月～2015年6月收治的180例肺结核病患者，按照随机数字表法将患者分为观察组与对照组，每组90例；患者均给予常规肺结核治疗，初期口服异烟肼片、盐酸乙胺丁醇胶囊、吡嗪酰胺片，对于复治患者均额外加用阿米卡星。观察组在上述同等用药的情况下加用利福平注射液和左氧氟沙星，观察两组治疗效果和不良反应。结果治疗效果组间差异具有统计学意义（P＜0.05），其中观察组治疗总有效率为97.8%，高于对照组的90.0%，差异具有统计学意义（P＜0.05）；观察组发生1例胃肠道不良反应，发生率为1.1%，对照组发生2例胃肠道不良反应，1例乏力，发生率为3.3%，差异无统计学意义（P＞0.05）。结论左氧氟沙星联合抗结核方案治疗肺结核临床效果显著，值得临床上推荐使用。

左氧氟沙星；肺结核；抗结核；有效率

［Abstract］Objective To investigate the c1inica1 effect of 1evof1oxacin combined with anti-tubercu1osis regimen in the treatment of pu1monary tubercu1osis.Methods 180 patients with pu1monary tubercu1osis treated in our hospita1 from January 2013 to June 2015 were co11ected and divided into the observation group and the contro1 group according to the random number tab1e method，with 90 patients in each group.A11 the patients were given conventiona1 pu1monary tubercu1osis treatment，which was ora1 administration of isoniazid tab1ets，ethambuto1 hydroch1oride capsu1es and pyrazinamide tab1ets in the initia1 stage，and retreated patients were given additiona1 administration of amikacin.The observation group was given additiona1 rifampicin injection and 1evof1oxacin on the basis of the above medication situation. The treatment effects and adverse reactions of the two groups were observed.Results The two groups had statistica11y significant differences in the treatment effects（P＜0.05）.The tota1 treatment effective rate of the observation group was 97.8%，which was higher than the 90.0%of the contro1 group，with statistica11y significant difference（P＜0.05）.In the observation group，1 case of gastrointestina1 adverse reaction occurred，with the occurrence rate of 1.1%，and in the contro1 group，2 cases of gastrointestina1 adverse reactions occurred，1 case of fatigue，with the occurrence rate of 3.3%，with statistica11y significant differences（P＞0.05）.Conclusion Levof1oxacin combined with anti-tubercu1osis regimen shows remarkab1e c1inica1 effects in the treatment of pu1monary tubercu1osis，thereby worthy of c1inica1 recommendation and app1ication.

［Key words］Levof1oxacin；Tubercu1osis；Anti-tubercu1osis；Effective rate

随着生活环境变化，越来越多人生活在空气质量相对较低的环境中，各种疾病发生率呈现明显上升趋势，其中肺结核就是高污染环境下的一种常见疾病［1］。肺结核病是一种全球性的疾病，其慢性危害十分巨大，已经成为影响人类健康的重要慢性传染病，我国是肺结核病高发国家，根据卫生部门在2015年发布的数据显示，我国肺结核病患者已经超过3000万人，并且每年还有100万以上的新增病例［2］。……