苏　丹　潘晓倩.哈尔滨市儿童医院，黑龙江哈尔滨　5000；.哈尔滨市二四二医院，黑龙江哈尔滨　50066

肾上腺素联合布地奈德交替雾化吸入治疗急性喉炎合并喉梗阻的疗效及安全性

苏丹1潘晓倩2
1.哈尔滨市儿童医院，黑龙江哈尔滨150010；2.哈尔滨市二四二医院，黑龙江哈尔滨150066

目的探讨肾上腺素联合布地奈德交替雾化吸入治疗急性喉炎合并喉梗阻的疗效及安全性。 方法选取2014年2月～2015年2月期间我院收治的60例急性喉炎合并喉梗阻患儿，按随机数字法将其分为观察组和对照组，每组30例。观察组采用肾上腺素联合布地奈德交替雾化吸入治疗，对照组采用布地奈德雾化吸入治疗，比较两组临床症状消失时间及住院时间、临床疗效及不良反应。结果观察组与对照组相比，声嘶［（13.9±1.3）h vs（20.3±1.8）h］、呼吸困难［（3.2±1.1）h vs（5.7±1.3）h］、喉鸣音［（11.5±1.4）h vs（17.7±1.6）h］的症状消失时间及住院时间［（28.7±2.5）h vs（48.3±2.8）h］各项指标差异有统计学意义（P＜0.05）；观察组治疗总有效率为96.7%，对照组为80.0%，两组总有效率差异具有统计学意义（P＜0.05）；两组均未观察到明显不良反应。结论采用肾上腺素联合布地奈德交替雾化吸入治疗急性喉炎合并喉梗阻，对改善患者的临床症状及体征效果显著，可以明显提高临床治疗效果，无明显不良反应，安全性好，值得临床推广。

肾上腺素；布地奈德；雾化吸入；急性喉炎；喉梗阻

［Abstract］Objective To investigate the efficacy and safety of epinephrine combined with budesonide a1ternate aeroso1 inha1ation in the treatment of acute 1aryngitis associated with 1aryngea1 obstruction.Methods Sixty chi1dren with acute 1aryngitis associated with 1aryngea1 obstruction treated in our hospita1 from February 2014 to February 2015 were divided into the contro1 group（budesonide aeroso1 inha1ation treatment）and the observation group（epinephrine combined with budesonide a1ternate aeroso1 inha1ation treatment）according to the random number method，with 30 patients in each group.The c1inica1 symptom disappearance time，1ength of stay，c1inica1 efficacy and adverse reactions of the two groups were compared.Results The observation group and the contro1 group were different in the disappearance time of hoarseness［（13.9±1.3）hours vs（20.3±1.8）hours］，dyspnea［（3.2±1.1）hours vs（5.7±1.3）hours］and throat singing song［（11.5±1.4）hours vs（17.7±1.6）hours］and the 1ength of stay［（28.7±2.5）hours vs（48.3±2.8）hours］，with statistica11y significant differences（P＜0.05）.The tota1 treatment effective rate of the observation group was 96.7%，which was significant1y higher than the 80.0%of the contro1 group，with statistica11y significant difference（P＜0.05）.No obvious adverse reaction occurred in either group during the treatment period.Conclusion Epinephrine combined with budesonide a1ternate aeroso1 inha1ation can significant1y improve the c1inica1 symptoms and signs of the patients with acute 1aryngitis associated with 1aryngea1 obstruction，can improve the c1inica1 efficacy and has high treatment safety，thereby worthy of c1inica1 promotion.

［Key words］Epinephrine；Budesonide；Aeroso1 inha1ation；Acute 1aryngitis；Laryngea1 obstruction

急性喉炎作为儿科比较常见的疾病之一，多由细菌或病毒感染所致［1，2］，其发生可能与患儿喉部及声门下区黏膜下组织松弛、喉软骨发育不完善、喉腔狭小、免疫力低下、淋巴血管相对丰富、咳嗽反射的排痰能力差等因素有关［3，4］，一旦发生感染就容易出现肿胀，造成上气道梗阻现象，患儿出现缺氧、缺血症状，甚至危及生命［5］。……